Publications by authors named "Kaireng Wu"
Hyperuricemia is a metabolic disorder characterized by elevated serum uric acid levels. Soluble urate can activate immune responses, and the excessive accumulation of urate in the kidneys results in hyperuricemic nephropathy (HN). However, the lack of an established HN model is a major obstacle to advancing research into the pathogenesis of HN and the development of novel drugs.
View Article and Find Full Text PDFArticle Synopsis
- Drug-induced liver injury (DILI) is when certain medicines hurt your liver, and it's a big cause of liver problems in the U.S. and Europe.
- Some drugs harm the liver directly, while others do it by causing stress in the body or making the immune system attack.
- Changes in the bacteria in our gut (gut microecology) can also make DILI worse, and looking after our gut health can help protect the liver from these injuries.
Ethnopharmacological Relevance: Excessive serum uric acid (SUA) causes hyperuricemic nephropathy (HN), characterized by inflammatory infiltration and tubulointerstitial fibrosis. Most recently, we demonstrated that Fufang Zhenzhu Tiaozhi (FTZ) capsule attenuated diabetic nephropathy through inhibition of renal inflammation and fibrosis. However, whether FTZ ameliorates HN is still unclear.
View Article and Find Full Text PDF