Publications by authors named "Kairen Chen"

The emergence of the coronavirus disease 2019 (COVID-19) pandemic prompted researchers to develop portable biosensing platforms, anticipating to detect the analyte in a label-free, direct, and simple manner, for deploying on site to prevent the spread of the infectious disease. Herein, we developed a facile wavelength-based SPR sensor built with the aid of a 3D printing technology and synthesized air-stable NIR-emitting perovskite nanocomposites as the light source. The simple synthesis processes for the perovskite quantum dots enabled low-cost and large-area production and good emission stability.

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Article Synopsis
  • * Researchers developed a phase-sensitive surface plasmon resonance (PS-SPR) biosensor using a new monoclonal antibody targeting the SARS-CoV-2 spike protein, demonstrating high sensitivity in detecting the virus compared to traditional testing methods.
  • * The PS-SPR biosensor showed a rapid detection capability with results in under 10 minutes, accurately measuring SARS-CoV-2 in various samples, thus proving to be a promising tool for clinical applications.
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Mental health literacy (MHL) plays an important role in public health. Improving MHL can promote mental health at the individual and public levels. To date, no published studies have assessed the effectiveness of MHL curriculum interventions among undergraduate public health students.

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Mitochondrial homeostasis plays essential role for the proper functioning of the kidney. NADH-ubiquinone oxidoreductase core subunit V1 (NDUFV1) is an enzyme in the complex I of electron transport chain (ETC) in mitochondria. In the present study, we examined the effects of NDUFV1 on renal function in unilateral ureteral obstruction (UUO) model mice.

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The SPR phenomenon results in an abrupt change in the optical phase such that one can measure the phase shift of the reflected light as a sensing parameter. Moreover, many studies have demonstrated that the phase changes more acutely than the intensity, leading to a higher sensitivity to the refractive index change. However, currently, the optical phase cannot be measured directly because of its high frequency; therefore, investigators usually have to use complicated techniques for the extraction of phase information.

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Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase belonging to class III histone deacetylases. Previous studies have shown that SIRT1 is involved in kidney physiology regulation and protects the kidney from various pathological factors. However, the underlying mechanisms behind its function have yet to be fully elucidated.

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Objective: To explore intergenerational differences on key factors of food parenting practices (FPPs) related to home eating behavior of schoolchildren.

Design: In-depth interviews with social recognition theory-based semistructured interviews conducted from December 2016 to January 2017.

Participants: Primary caregivers of elementary schoolchildren from 23 households (16 parents, 14 grandparents) in 4 remote areas of Hualien, Taiwan.

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Left ventricular remodeling commonly complicates end-stage renal disease following chronic kidney disease (CKD). This study investigated the therapeutic efficacy of resveratrol (RSV), a polyphenolic compound, on left ventricular remodeling in subtotal nephrectomy rats and sought to uncover the underlying molecular mechanisms. Subtotal nephrectomy caused renal dysfunction, such as gradual increases in serum creatinine and blood urea nitrogen, glomerular sclerosis, and tubulointerstitial fibrosis.

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Sleep quality is an important issue in nurses' mental and general health. Long-term psychological distress leads to increased sleep disturbances among nurses. However, which forms of psychological distress are most associated with sleep disturbances is unclear among female nurses.

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Purpose: To explore the state of mental treatment, heart rate variability (HRV), level of aggressive behavior, and their relationships among hospitalized patients with schizophrenia.

Design And Methods: This study adopted a follow-up design and convenience sampling. Thirty-three subjects completed the questionnaire, and their HRV indices were measured.

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Background/purpose: Diabetic ketoacidosis (DKA) is a fatal complication of diabetes, and is strongly related to the quality of diabetes care. This study aimed to establish recent secular trends of incidence density (ID) of DKA in patients with diabetes in Taiwan and to explore the effects of age and sex on the risk of a DKA emergency.

Methods: Using the National Health Insurance claims data, we identified annual diabetic cohorts (around 650,000 diabetic patients annually) from 1997 to 2005, and searched for possible admissions due to DKA emergencies.

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Objectives: Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes mellitus, and its risks can be largely reduced by adequate and high-quality ambulatory diabetic care. The aim of this study is to assess the risk and frequency of developing DKA in relation to the specialty of doctors who provide diabetes cares.

Methods: In searching for possible episodes of hospitalization due to DKA (ICD-9-CM: 250.

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