Development of Ru-polypyridyl complexes for real-time monitoring of Aβ oligomers and inhibition of Aβ fibril formation.

The aggregation of amyloid-β (Aβ) is one of the important pathological markers of Alzheimer's disease. Ruthenium(II) complexes have good stability, low cytotoxicity, a high fluorescence quantum yield, and a good Stokes shift as fluorescent probes. Based on this, we constructed a fluorescent probe for real-time imaging and inhibition of Aβ-fibril formation using a complex of Ru polypyridine with organic fluorophores (,-dimethylaniline) and hydrophobic peptides (KLVFF).