Platelet FcRγ inhibits tumor metastasis by preventing the colonization of circulating tumor cells.

Fc receptor γ subunit (FcRγ) activation plays a crucial role in cancer carcinogenesis. Here, we aimed to uncover the impact of FcRγ on circulating tumor cells (CTC) colonization and the underlying mechanism. FcRγ deficient (FcRγ) mice were used to investigate the functional effects of FcRγ in cancer metastasis, and the results demonstrated that FcRγ deficiency significantly promotes metastasis.

Antioxidant and anti-inflammatory activities of an anti-diabetic polysaccharide extracted from Gynostemma pentaphyllum herb.

This work aimed to determine the antioxidant and anti-inflammatory effects of an anti-diabetic polysaccharide (GPP) extracted from Gynostemma pentaphyllum herb on diabetic mice. In vitro antioxidant assays showed that the DPPH radical, hydroxyl radical, superoxide anion, and ABTS radical scavenging activities of GPP increased in a dose-dependent manner. Animal experiments demonstrated that GPP could efficiently reduce the body weight and fasting blood sugar of diabetic mice and decrease the blood parameters of ALP, ALT, AST, and BUN.