Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export.

The asymptomatic nature of cholangiocarcinoma (CCA), particularly during its early stages, in combination with its high aggressiveness and chemoresistance, significantly compromises the efficacy of current therapeutic options, contributing to a dismal prognosis. As a tumor suppressor that inhibits the cell cycle, abnormal cytoplasmic p27kip1 localization is related to chemotherapy resistance and often occurs in various cancers, including CCA. Nevertheless, the underlying mechanism is unclear.

Typical layered structure bismuth-based photocatalysts for photocatalytic nitrogen oxides oxidation.

Traditional NO treatment methods require external reducing reagents and harsh reaction conditions, which is not conducive to effectively eliminate NO at low concentration, especially at ppb levels. Fortunately, low concentration NO can be removed by photocatalytic oxidation under mild reaction conditions. Bismuth (Bi)-based photocatalysts with the layered structure have obtained considerable concerns of photocatalytic NO oxidation.

RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus.

Among the hallmarks of cholangiocarcinoma (CCA) progression and unresponsiveness to therapy is impaired ubiquitin-dependent degradation of nuclear tumor suppressor protein. In the previous stage, our research group found that as a key tumor suppressor, nuclear dysfunction of p27kip1 is closely related to chemotherapy resistance of CCA, but the specific mechanism is unclear. It was recently shown that p27kip1-driven tumors were strongly dependent on the SUMO pathway.

Enhanced photocatalytic activity of 3D hierarchical RP/BP/BiOCOOH via oxygen vacancies and double heterojunctions.

A 3D hierarchical RP/BP/BiOCOOH double heterostructures with abundant oxygen vacancies (OVs) was obtained by hydrothermal process and its photocatalytic activity was investigated by degradation of TC-HCl with different light sources and various natural water. The physicochemical characteristics of RP/BP/BiOCOOH heterojunctions were systematically characterized via TEM, XPS, EPR, EIS et al. Compared with BiOCOOH, the photocatalytic activity of RP/BP/BiOCOOH was obviously enhanced.

Self-assembled micro-flowers of ultrathin Au/BiOCOOH nanosheets photocatalytic degradation of tetracycline hydrochloride and reduction of CO.

The low separation efficiency of carriers and weak light response of photocatalysts severely limit the application of photocatalysis technology. Herein, we prepared a visible light responsive self-assembled micro-flowers of ultrathin bismuth oxide formate nanosheets supported by gold nanoparticles (Au/BiOCOOH) composite photocatalyst via hydrothermal method. The physicochemical and photoelectric properties of obtained-photocatalysts were completely analyzed via a range of characterization means.