Publications by authors named "Kainat Gul"
L. edodes (L. edodes) is the most consumed mushroom in the world and has been well known for its therapeutic potential as an edible and medicinal candidate, it contains dietary fibers, vitamins, proteins, minerals, and carbohydrates.
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- - The SARS-CoV-2 Omicron variant, along with its rapidly spreading sublineages and emerging hybrid variants, poses the risk of new future waves due to its ability to evolve quickly.
- - This study analyzes the spike protein's interaction with the ACE2 receptor and highlights hydration forces and mutations in hydrophobic and hydrophilic residues, particularly in Delta and Omicron variants, which can influence viral behavior and evolution.
- - The research underscores the significant role of hydration forces in protein dynamics and conformation, suggesting that understanding these interactions is crucial for developing effective COVID-19 treatment strategies.
Roxadustat, a small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 2 (HIF-PHD2) has been recently overruled by the American Food and Drug Administration (FDA) in Phase 3 clinical trials. This study provides insights into the dynamics of Roxadustat with PHD2 and proposes two FDA-approved drugs; Pemetrexed and Valrubicin to treat chronic kidney disease (CKD). Role of chemical scaffolds such as synthetic pyrimidine-based antifolate is found critical for PHD2 inhibitory activity, which is concurrent with the experimental findings for stimulating Endogenous erythropoietin (EPO) gene expression.
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