Clinical efficacy of transcutaneous pelvic floor magnetic stimulation combined with urination training in the treatment of overactive bladder in children.

Objective: This study aimed to evaluate the clinical effect of transcutaneous pelvic floor magnetic stimulation combined with urination training in the treatment of overactive bladder (OAB) in children.

Methods: In this study, the clinical data of 42 children with OAB who were treated with transcutaneous pelvic floor magnetic stimulation combined with the urination training method at our hospital from March 2022 to December 2022 (Group B) were collected. The clinical data of 50 children with OAB who were treated with the urination training method at our hospital from December 2021 to February 2022 (Group A) were used as controls.

Synergistic Anticancer Strategy Targeting ECM Stiffness: Integration of Matrix Softening and Mechanical Signal Transduction Blockade in Primary Liver Cancers.

The development of primary liver cancer (hepatocellular carcinoma [HCC] and intrahepatic cholangiocarcinoma [ICC]) is linked to its physical microenvironment, particularly extracellular matrix (ECM) stiffness. Potential anticancer strategies targeting ECM stiffness include prevention/reversal of the stiffening process and disruption of the response of cancer cells to mechanical signals from ECM. However, each strategy has limitations.

Screening of PDSS1 as a Potential Biomarker for Hepatocellular Carcinoma Based on a Copper-Related Prognostic Signature through Bulk and Single-cell RNA-sequencing Analysis.

Currently, there is few literature comprehensively analyzing landscape of cuproptosis-related genes (CRGs) in liver hepatocellular carcinoma (LIHC) with multiple omics approaches. Using comprehensive analysis, we aim to find out how CRGs works on LIHC. With data from The Cancer Genome Atlas (TCGA) database, we constructed a prognostic prediction model for CGRs using LASSO regression analysis and performed immune infiltration analysis using the same dataset.

Continuous nursing for infants with congenital talipes equinovarus undergoing Ponseti therapy and telehealth education for their parents via WeChat: a single center retrospective study.

Aims: This study aimed to evaluate the impact of continuous nursing and telehealth education via WeChat in infants with congenital talipes equinovarus (CTEV) undergoing Ponseti therapy on reducing complications, care burden, and improving the quality of life for parents.

Methods: This is a single-center retrospective study. From July 2021 to December 2022, 44 CTEV children who undergoing Ponseti treatment in our hospital who received continuous nursing and telehealth education via WeChat (experimental group).

Erratum to "Research trends in cholangiocarcinoma treatments during the last 3 decades" [Heliyon 9(7) (July 2023) e17100].

[This corrects the article DOI: 10.1016/j.heliyon.

Effects of eyeshades in sleep quality and pain after surgery in school-age children with supracondylar humeral fractures.

Objective: This study aimed to explore the effects of eye masks on the sleep quality and pain of children over 5 years old with humeral supracondylar fracture after surgery.

Methods: Fifty children with humeral supracondylar fracture who underwent closed reduction and percutaneous pinning (CRPP) in the Pediatric orthopaedic Department of a provincial hospital in China from February 2020 to December 2021 were selected. The children were randomly divided into the experimental group ( = 25) and the control group ( = 25).

Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation.

Background: Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor prognosis. The underlying functions and mechanisms of circular RNA and SUMOylation in the development of ICC remain poorly understood.

Methods: Circular RNA hsa_circ_0001681 (termed Circ-RAPGEF5 hereafter) was identified by circular RNA sequencing from 19 pairs of ICC and adjacent tissue samples.

Research trends in cholangiocarcinoma treatments during the last 3 decades.

Background: Over the past 30 years, numerous studies have focused on the treatment of cholangiocarcinoma (CCA), and these treatments have greatly evolved.

Objectives: To better understand the research trends, we evaluated the most influential publications and attempted to identify their characteristics using bibliometric methods.

Methods: The most influential publications were identified from the Clarivate Analytics Web of Science Core Collection database.

The causal relationship between abdominal obesity and lower bone mineral density: A two-sample mendelian randomization study.

The purpose of this study was to assess the causal effect of abdominal obesity on bone mineral density by two-sample Mendelian randomization (MR). Abdominal obesity was chosen as exposure in this study. Single nucleotide polymorphisms, extracted from Genome-wide association analysis (GWAS) data, which are closely associated with waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) were used as instrumental variables to perform MR studies.

Circulating Adipokine Levels in Nonobese Women With Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis.

Levels of circulating adipokines in nonobese polycystic ovary syndrome (PCOS) patients have been reported in many studies. However, the results are inconsistent. The aim of this meta-analysis is to assess whether the levels of circulating adipokines are changed in nonobese PCOS relative to nonobese healthy controls.

Using machine learning techniques predicts prognosis of patients with Ewing sarcoma.

Ewing sarcoma is one of the most common types of malignant bone tumor in children and adolescents. However, to our limited knowledge, no study exists that uses machine learning to create algorithms for the prediction of survivorship for Ewing sarcoma. About 2332 patients with Ewing sarcoma between 1975 and 2016 in the United States were identified from Surveillance, Epidemiology, and End Results (SEER) program.

Identifying Children With Poor Cochlear Implantation Outcomes Using Massively Parallel Sequencing.

Cochlear implantation is currently the treatment of choice for children with severe to profound hearing impairment. However, the outcomes with cochlear implants (CIs) vary significantly among recipients. The purpose of the present study is to identify the genetic determinants of poor CI outcomes.

Gradenigo syndrome caused by nontuberculous mycobacteria.

Gradenigo syndrome is a rare but devastating complication of otitis media that involves the petrous apex. Clinically, it is characterized by the triad of suppurative otitis media, deep facial pain, and abducens palsy. Most of the Gradenigo syndrome cases that have been reported in the literature were caused by pyogenic bacteria.

Intratympanic dexamethasone on cochlear blood flow in Guinea pigs.

Unlabelled: To determine the effect of intratympanically delivered dexamethasone on cochlear blood flow. 29 white Hartly guinea pigs were divided into 2 groups. By laser Doppler flowmeter, baseline data were recorded in the first 15-20 min, followed by 20 min' recording after applying dexamethasone or normal saline, with a record of flow every 5 min in 2 groups.

Postoperative intensity-modulated radiotherapy for squamous cell carcinoma of the external auditory canal and middle ear: treatment outcomes, marginal misses, and perspective on target delineation.

Purpose: To report outcomes of the rare disease of squamous cell carcinoma (SCC) of the external auditory canal (EAC) and middle ear treated with surgery and postoperative intensity-modulated radiotherapy (IMRT). Failure patterns related to spatial dose distribution were also analyzed to provide insight into target delineation.

Methods And Materials: A retrospective review was conducted of the records of 11 consecutive patients with SCC of the EAC and middle ear who were treated with curative surgery and postoperative IMRT at one institution between January 2007 and February 2010.

Hearing in noise test in subjects with conductive hearing loss.

Background/purpose: It has been reported that patients with pure conductive hearing loss (CHL) have remarked that their hearing is better in the presence of background noise. This study investigated the ability for speech discrimination under background noise in adult subjects with CHL, using the Mandarin Hearing in Noise Test (M-HINT).

Methods: Seventeen subjects with unilateral CHL and 15 with bilateral CHL participated in this study.

Prenatal risk factors and occurrence of allergic rhinitis among elementary school children in an urban city.

Objectives: To investigate the incidence and prenatal risk factors for allergic rhinitis among elementary school children in an urban city.

Study Design: Risk factor data were collected by questionnaire and direct physical examination. Multiple logistic regression analysis was used to calculate the odds ratios of developing allergic rhinitis among children 6-13 years of age.

Microdebrider-assisted versus radiofrequency-assisted inferior turbinoplasty.

Objectives: The study aimed to evaluate the long-term efficacy of microdebrider-assisted inferior turbinoplasty (MAIT) compared to radiofrequency-assisted inferior turbinoplasty (RAIT) for hypertrophic inferior turbinates.

Study Design: Surgical outcomes were evaluated using the visual analogue scale, anterior rhinomanometry, and saccharin test results.

Methods: From January 2001 to December 2006 inclusively, 120 patients with persistent allergic rhinitis, chronic nasal obstruction, and hypertrophic inferior turbinates were enrolled in this study, randomly classified, and underwent either MAIT (n = 60) or RAIT.

Effect of endoscopic sinus surgery on irradiation-induced rhinosinusitis in patients with nasopharyngeal carcinoma.

Objectives: We evaluated the effect of endoscopic sinus surgery on irradiation-induced rhinosinusitis of the maxillary-sinus mucosa among patients with nasopharyngeal carcinoma (NPC).

Design: Surgical outcomes were evaluated by changes to the ultrastructure of the antral mucosa and nasomucociliary clearance.

Methods: Twenty-one NPC patients with irradiation-induced chronic sinusitis were enrolled in the study, along with five controls.

Effects of Meropack in the middle meatus after functional endoscopic sinus surgery in children with chronic sinusitis.

Objectives: The aim of the study was to evaluate the effects and morbidities of Meropack, an absorbable hyaluronic acid packing material, placed in the middle meatus after endoscopic sinus surgery in children with chronic sinusitis.

Methods: Sixty consecutive children with similar degrees of bilateral chronic sinusitis were enrolled in the study. Meropack was randomly inserted into one side of the middle meatus, while the opposite sinus was not packed after functional endoscopic sinus surgery.

Chronologic changes of nitric oxide concentration in the cochlear lateral wall and its role in noise-induced permanent threshold shift.

Objective: The objective of this study was to investigate the chronologic changes of nitric oxide (NO) concentration in the cochlear lateral wall and to explore its possible role in permanent threshold shift (PTS) after intense noise exposure.

Materials And Methods: Seventeen guinea pigs were subjected to a single continuous exposure to broadband white noise at 105 +/- 2 dB sound pressure level (SPL) for 40 hours and were divided into four groups according to various postnoise recovery periods. Another 12 guinea pigs were not exposed to noise and served as controls.

Mucosal healing and mucociliary transport change after endoscopic sinus surgery in children with chronic maxillary sinusitis.

Objectives: The aim of the study was to evaluate the effects of endoscopic sinus surgery for chronic maxillary sinusitis in children by investigating ultrastructure element changes in the sinus mucosa and nasal mucociliary clearance before and after operation.

Methods: Twenty-five children with chronic maxillary sinusitis scheduled to undergo functional endoscopic sinus surgery and another five controls were enrolled. A saccharin transit test was performed before and after the operation for each subject.

Normalization of maxillary sinus mucosa after functional endoscopic sinus surgery in pediatric chronic sinusitis.

Objectives: To observe the recovery of maxillary sinus mucosa after endoscopic sinus surgery in children with chronic maxillary sinusitis. Functional endoscopic sinus surgery (FESS) was used to perform a middle meatal antrostomy, leaving the antral mucosa intact for later observation.

Methods: Between January 1998 and December 2003, 43 children with chronic sinusitis were enrolled in the study.