Post-stroke seizures, epilepsy, and mortality in a prospective hospital-based study.

Background And Objectives: Post-stroke epilepsy (PSE) is a significant concern in the elderly population, with stroke being a leading cause of epilepsy in this demographic. Several factors have shown consistent associations with the risk of developing PSE, including cortical lesions, initial stroke severity, younger age, and the occurrence of early seizures. The primary objectives of this study were two-fold: (1) to determine the incidence of PSE and (2) to identify the risk factors associated with PSE in a prospective cohort of post-stroke patients.

Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis.

Background: Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome.

Methods: We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions.

[Long-term postoperative outcomes in patients with drug-resistant epilepsy].

Unlabelled: Epilepsy surgery is effective in 30-82% of patients with drug-resistant epilepsy. However, risk factors of unfavorable outcomes after epilepsy surgery require further study.

Objective: To evaluate risk factors of favorable and unfavorable long-term postoperative outcomes in patients with drug-resistant epilepsy.

[Electroencephalography in acute stroke].

Objective: To determine the incidence of non-convulsive status epilepticus, epileptiform activity, rhythmic and periodic patterns in patients with acute stroke.

Material And Method: An analysis of electroencephalography (EEG) in 86 stroke patients in the neurointensive care unit of the tertiary medical center was performed. Criteria for starting EEG recording were epileptic seizures or clinical suspicion of uncontrolled epileptic status.

[Posttraumatic seizures: a prospective cohort study].

Aim: To evaluate the incidence and risk factors for posttraumatic seizures (PTS).

Material And Methods: The authors conducted a prospective study of 237 patients with TBI of varying severity. The patients were hospitalized and examined in Moscow neurosurgery departments.

[Pharmacoeconomic aspects of monotherapy of focal epilepsy].

Aim: To perform a clinical/economic comparison of monotherapy with antiepileptic drugs (AED) in patients with newly diagnosed focal epilepsy (FE) based on the results of previous studies.

Material And Methods: The most common AEDs (carbamazepine (CBZ), oxcarbazepine (OXZ), lamotrigine (LTG), lacosamide (LCM)) were compared in patients, aged 16 years and over, with illness duration of five years.

Results And Conclusion: CBZ, OXZ and LCM can be used as monotherapy in patients with newly diagnosed FE.

[Outcomes of surgical treatment of patients with pharmacoresistant epilepsy].

Aim: To evaluate the results of surgical treatment of patients with pharmacoresistant epilepsy.

Material And Methods: Examination and surgical treatment of 61 patients with pharmacoresistant forms of symptomatic epilepsy were performed from 01.01.

The direct costs of epilepsy in Russia. A prospective cost-of-illness study from a single center in Moscow.

Objective: The objective of this study was to investigate prospectively the direct costs of epilepsy in Russia, taking a patient perspective and a bottom-up approach.

Methods: The study was conducted in adolescents and adults with epilepsy seen in the ambulatory services of a city hospital in Moscow. Patients were assigned to different prognostic categories: newly diagnosed epilepsy; epilepsy in remission for 2+years; epilepsy in remission for <2years or with occasional seizures; active, nondrug-resistant epilepsy; drug-resistant epilepsy; and drug-resistant epilepsy in surgical candidates.