Case Report: Two Patients With EGFR Exon 20 Insertion Mutanted Non-Small Cell Lung Cancer Precision Treatment Using Patient-Derived Xenografts in Zebrafish Embryos.

Background: Epidermal growth factor receptor (EGFR) exon 20 insertion mutations are uncommon EGFR mutations and generally resistant to first- and second-generation EGFR-tyrosine kinase inhibitors (TKIs). In precision oncology, treatment regimens are tested for improving the clinical outcomes. Zebrafish embryo tumor transplant models are used in cancer research.

Changes in aerobic fermentation and microbial community structure in food waste derived from different dietary regimes.

This study aimed to analyze the relationship between food components and food waste aerobic fermentation efficiency. Different food wastes were designed to be reflective of different dietary regimes, including formulated (R1), high oil/fat and salt (R2), high oil/fat and sugar (R3), and vegetarian (R4) diets, after which the physicochemical properties, enzyme activity, and structural characteristics of food waste microbial communities were examined to explore the potential mechanisms of food waste degradation under different dietary regimes. The main results of this study demonstrated that the physicochemical properties and hydrolase activity of different food waste were significantly different.

Characteristics of gut microbiota and its response to a Chinese Herbal Formula in elder patients with metabolic syndrome.

Alterations in gut microbiota have been known to play a critical role in metabolic syndrome. However, the microbial features in elderly patients with metabolic syndrome remain unclear. A traditional Chinese Herbal Formula, Yangyin Tiluo Decoction (YTD), can alleviate metabolic syndrome and cardiovascular disease.