Publications by authors named "Kailyn Gillick"
Article Synopsis
- Adult T-cell leukemia/lymphoma (ATLL) has poor treatment outcomes, but allogeneic stem-cell transplantation (allo-SCT) shows promise, despite limited data.
- In a study involving 100 ATLL patients, 17 underwent allo-SCT with notable improvements in 3-year progression-free survival (31%) and overall survival (35%), compared to autologous SCT (ASCT) which had a higher relapse incidence.
- Factors such as achieving a complete response, a high Karnofsky score, and ethnicity influenced survival outcomes, indicating that allo-SCT may offer long-term survival benefits for select ATLL patients.
Background: Adoptive immunotherapy using CD19-targeted Chimeric antigen receptor T cells (CAR-T) has revolutionized the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Data is limited on the propensity of infections and lymphohematopoietic reconstitution after Day 30 (D30) following CAR-T cell therapy. In this study, we evaluated the prevalence and nature of infectious complications in an expanded cohort of DLBCL patients treated with CD19 CAR-T therapy and its association with the dynamics of leukocyte subpopulation reconstitution post-CAR-T cell therapy.
View Article and Find Full Text PDF