Economic evaluation of serplulimab plus chemotherapy as the first-line treatment of oesophageal squamous cell carcinoma in China.

Objective: The ASTRUM-007 study confirmed the significant efficacy and safety of serplulimab plus chemotherapy for patients with locally advanced/metastatic, programmed cell death-ligand 1 positive oesophageal squamous cell carcinoma (OSCC). The economics of this regimen, however, is unclear. Therefore, this study aimed to evaluate the cost-effectiveness of adding serplulimab to chemotherapy for the treatment of advanced OSCC from the perspective of the Chinese healthcare system.

A new one-dimensional Ni coordination polymer with a two-dimensional supra-molecular architecture.

A new one-dimensional Ni coordination polymer of 1,3,5-tris-(imidazol-1-ylmeth-yl)benzene, namely -poly[[aqua-(sulfato-κ)hemi(μ-ethane-1,2-diol-κ:')[μ-1,3,5-tris-(1-imidazol-1-ylmeth-yl)benzene-κ,,]nickel(II)] ethane-1,2-diol monosolvate monohydrate], {[Ni(SO)(CHN)(CHO)(HO)]·CHO·HO} , was synthesized and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction. The Ni cation is coordinated by three N atoms of three different 1,3,5-tris-(imidazol-1-ylmeth-yl)benzene ligands, one O atom of an ethane-1,2-diol mol-ecule, by a sulfate anion and a water mol-ecule, forming a distorted octa-hedral NiNO coordination geometry. The tripodal 1,3,5-tris-(imidazol-1-ylmeth-yl)benzene ligands link the Ni cations, generating metal-organic chains running along the [100] direction.

Bis(6-nitro-1,10-phenanthrolin-1-ium) 2,5-di-carb-oxy-terephthalate.

In the structure of the title 2:1 proton-transfer compound, 2C12H8N3O2 (+)·C10H4O8 (2-), the 6-nitro-1,10-phenanthroline mol-ecules act as proton sponges, accepting protons from pyromellitic acid. The -NO2 group of one of the 6-nitro-1,10-phenanthrolin-1-ium cations is disordered and was refined with a site-occupancy ratio of 0.624 (15):0.

A novel three-dimensional Zn(II) coordination polymer with 1,3,5-tris(imidazol-1-ylmethyl)benzene and cyclohexane-1,3,5-tricarboxylate ligands.

In the Zn(II) compound poly[[bis(μ3-cyclohexane-1,3,5-tricarboxylato)bis[μ3-1,3,5-tris(imidazol-1-ylmethyl)benzene]trizinc(II)] hexahydrate], {[Zn3(C18H18N6)2(C9H9O6)2]·6H2O}n, based on mixed 1,3,5-tris(imidazol-1-ylmethyl)benzene and cyclohexane-1,3,5-tricarboxylate ligands, there are two types of crystallographically independent Zn(II) centres, one in a general position and one on a crystallographic twofold axis. They have similar fourfold distorted tetrahedral coordination geometries, ligated by two monodentate carboxylate groups from two cyclohexane-1,3,5-tricarboxylate ligands and by two N atoms from two 1,3,5-tris(imidazol-1-ylmethyl)benzene ligands. The cyclohexane-1,3,5-tricarboxylate anions link the Zn(II) cations to generate a two-dimensional layered metal-organic structure running parallel to the (201) plane.

2,9-Dimethyl-1,10-phenanthrolin-1-ium 2,4,5-tri-carb-oxy-benzoate monohydrate.

In the preparation of the title hydrated salt, C14H13N2 (+)·C10H5O8 (-)·H2O, a proton has been transfered to the 2,9-dimethyl-1,10-phenanthrolinium cation, forming a 2,4,5-tri-carb-oxy-benzoate anion. In the anion, the mean planes of the protonated carboxyl-ate groups form dihedral angles of 11.0 (5), 4.

Bis(1,10-phenanthroline-κ(2) N,N')(sulfato-κ(2) O,O')nickel(II) propane-1,2-diol monosolvate.

In the title compound, [Ni(SO4)(C12H8N2)2]·C3H8O2, the Ni(II) atom exhibits a distorted octa-hedral coordination by four N atoms from two chelating 1,10-phenanthroline ligands and two O atoms from an O,O'-bidentate sulfate group. A twofold rotation axis passes through the Ni and S atoms and the mid-point of the hydroxyl C-C bond of the propane-1,2-diol solvent mol-ecule. The dihedral angle between the two chelating N2C2 groups is 85.

Two-dimensional hydrogen-bonded supramolecular networks in the compounds of benzene-1,2,4,5-tetracarboxylic acid (pyromellitic acid) with 2,2'-biimidazole and 4,4'-dimethyl-2,2'-bipyridine.

Two products from the proton-transfer reactions of benzene-1,2,4,5-tetracarboxylic acid (pyromellitic acid, PMA) with 2,2'-biimidazole and 4,4'-dimethyl-2,2'-bipyridine, namely 2,2'-biimidazole-3,3'-diium 2,5-dicarboxybenzene-1,4-dicarboxylate, C6H8N4(2+),C10H4O8(2-), (I), and 4-methyl-2-(4-methylpyridin-2-yl)pyridinium 2,4,5-tricarboxybenzoate monohydrate, C12H13N2(+)·C10H5O8(-)·H2O, (II), have been prepared and their structures determined. Both compounds crystallize in the space group P1. The asymmetric unit of (I) is composed of two independent ion pairs.

Bis(1,10-phenanthroline-κ(2) N,N')(sulfato-κO)zinc(II) propane-1,2-diol monosolvate.

In the title compound, [Zn(SO4)(C12H8N2)2]·C3H8O2, the Zn(II) ion is in a distorted square-pyramidal coordination environment composed of four N atoms from two chelating 1,10-phenanthroline ligands and one O atom from a monodentate sulfate ligand. The Zn(II) ion lies on a twofold rotation axis. The sulfate ligand and propane-1,2-diol mol-ecules are disordered across the twofold rotation axis.

Poly[diaqua-bis-(μ-4,4'-bipyridine-κ(2) N:N')bis-(ethane-1,2-diol-κO)bis(μ-sulfato-κ(2) O:O')dicobalt(II)].

In the title compound, [Co2(SO4)2(C10H8N2)2(C2H6O2)2(H2O)2] n , there are two crystallographically independent Co(II) ions, each of which lies on a twofold rotation axis and has a slightly distorted octa-hedral environment. One Co(II) ion is coordinated by two N atoms from two bridging 4,4'-bipyridine (4,4'-bipy) ligands, two O atoms from two sulfate ions and two O atoms from aqua ligands. The second Co(II) ion is similar but with ethane-1,2-diol ligands in place of water mol-ecules.

Poly[aqua-(μ2-4,4'-bipyridine-κ(2) N:N')(ethane-1,2-diol-κO)(μ2-sulfato-κ(2) O:O')nickel(II)].

The title compound, [Ni(SO4)(C10H8N2)(C2H6O2)(H2O)] n , contains two crystallographically unique Ni(II) atoms, each lying on a twofold rotation axis and having a slightly distorted octa-hedral environment. It is isotypic with the previously reported Cu(II) analog [Zhong et al. (2011 ▶).

Bis(1,10-phenanthroline-κ(2) N,N')(sulfato-O)copper(II) butane-2,3-diol monosolvate.

The title compound, [Cu(SO4)(C12H8N2)2]·C4H10O2, is comprised of neutral monomeric complex and butane-2,3-diol solvent mol-ecules. In the complex, the Cu(II) ion is in a distorted square-pyramidal coordination environment defined by four N atoms from two chelating 1,10-phenanthroline ligands and one O atom from a monodentate sulfate anion; the O atom is at the apex. The two chelating N2C2 groups subtend a dihedral angle of 85.

Bis(1,10-phenanthroline-κ(2) N,N')(sulfato-κ(2) O,O')cobalt(II) propane-1,2-diol monosolvate.

In the title compound, [Co(SO4)(C12H8N2)2]·C3H8O2, the Co(II) atom (site symmetry 2) has a distorted octa-hedral coordination composed of four N atoms from two chelating 1,10-phenanthroline ligands and two O atoms from an O,O'-bidentate sulfate ligand, in which the S atom has site symmetry 2. The dihedral angle between the two chelating N2C2 groups is 84.46 (15)°.

Bis(1,10-phenanthroline-κ(2) N,N')(sulfato-O)copper(II) propane-1,3-diol monosolvate.

In the title compound, [Cu(SO4)(C12H8N2)2]·C3H8O2, the Cu(II) ion is bonded to two chelating 1,10-phenanthroline (phen) ligands and one O atom from a monodentate sulfate ligand in a distorted square-based pyramidal arrangement, with the O atom in a basal site. The two chelating N2C2 groups subtend a dihedral angle of 71.10 (15)°.

Bis(1,10-phenanthroline-κ(2) N,N')(sulfato-κ(2) O,O')nickel(II) butane-2,3-diol monosolvate.

In the title compound, [Ni(SO4)(C12H8N2)2]·C4H10O2, the Ni(II) ion is six-coordinated by four N atoms from two chelating 1,10-phenanthroline ligands and two O atoms from an O,O'-bidentate sulfate anion, resulting in a distorted octa-hedral geometry for the metal ion. The dihedral angle between the two chelating N2C2 groups is 83.82 (12)°.

Poly[diaqua-(μ(4)-2,5-dicarb-oxy-benzene-1,4-dicarboxyl-ato-κ(4)O(1):O(2):O(4):O(5))(μ(2)-2,5-dicarb-oxy-benzene-1,4-dicarboxyl-ato-κ(2)O(1):O(4))bis-(1,10-phenanthroline-κ(2)N,N')dimanganese(II)].

In the title compound, [Mn(2)(C(10)H(4)O(8))(2)(C(12)H(8)N(2))(2)(H(2)O)(2)](n), the Mn(2+) ion has a slightly distorted octa-hedral N(2)O(4) coordination geometry being coordinated by one aqua O atom, two N atoms of the chelating 1,10-phenanthroline ligand and three carboxyl O atoms from three 2,5-dicarb-oxy-benzene-1,4-dicarboxyl-ate (H(2)btec(2-)) ligands. The H(2)btec(2-) anion exhibits two different coordination modes, viz. μ(2) and μ(4).

A novel one-dimensional Co(II) coordination polymer: catena-poly[[hexaaquacobalt(II)] [[diaquabis(sulfato-κO)cobalt(II)]-μ-4,4'-bipyridine-κ2N:N'] [[triaqua(sulfato-κO)cobalt(II)]-μ-4,4'-bipyridine-κ2N:N']].

The title compound, {[Co(H(2)O)(6)][Co(SO(4))(C(10)H(8)N(2))(H(2)O)(3)][Co(SO(4))(2)(C(10)H(8)N(2))(H(2)O)(2)]}(n), contains three crystallographically unique Co(II) centres, all of which are in six-coordinated environments. One Co(II) centre is coordinated by two bridging 4,4'-bipyridine (4,4'-bipy) ligands, one sulfate ion and three aqua ligands. The second Co(II) centre is surrounded by two N atoms of two 4,4'-bipy ligands and four O atoms, i.

Tris(1,10-phenanthroline-κ2N,N')iron(II) bis(2,4,5-tricarboxybenzoate) monohydrate and tris(2,2'-bipyridine-κ2N,N')iron(II) 2,5-dicarboxybenzene-1,4-dicarboxylate-benzene-1,2,4,5-tetracarboxylic acid-water (1/1/2).

The title compounds, tris(1,10-phenanthroline-κ(2)N,N')iron(II) bis(2,4,5-tricarboxybenzoate) monohydrate, [Fe(C(12)H(8)N(2))(3)](C(10)H(5)O(8))(2)·H(2)O, (I), and tris(2,2'-bipyridine-κ(2)N,N')iron(II) 2,5-dicarboxybenzene-1,4-dicarboxylate-benzene-1,2,4,5-tetracarboxylic acid-water (1/1/2), [Fe(C(10)H(8)N(2))(3)](C(10)H(4)O(8))·C(10)H(6)O(8)·2H(2)O, (II), were obtained during an attempt to synthesize a mixed-ligand complex of Fe(II) with an N-containing ligand and benzene-1,2,4,5-tetracarboxylic acid via a solvothermal reaction. In both mononuclear complexes, each Fe(II) metal ion is six-coordinated in a distorted octahedral manner by six N atoms from three chelating 1,10-phenanthroline or 2,2'-bipyridine ligands. In compound (I), the Fe(II) atom lies on a twofold axis in the space group C2/c, whereas (II) crystallizes in the space group P2(1)/n.

Diaqua-bis-(1,10-phenanthroline-κN,N')cadmium sulfate hexa-hydrate.

The title compound, [Cd(C(12)H(8)N(2))(2)(H(2)O)(2)]SO(4)·6H(2)O, was obtained unexpectedly during an attempt to synthesize a cadmium complex with bidentate bridging sulfate ligands via hydro-thermal synthesis. The Cd(II) metal ion is six-coordinated by two chelating 1,10-phenanthroline ligands and two water mol-ecules, resulting in a distorted octa-hedral geometry for the metal ion. The two chelating N(2)C(2) groups are almost perpendicular to each other [dihedral angle = 86.

Tris(1,10-phenanthroline-κN,N')nickel(II) bis-(2,4,5-tricarb-oxy-benzo-ate) monohydrate.

In the title compound, [Ni(C(12)H(8)N(2))(3)](C(10)H(5)O(8))(2)·H(2)O, the Ni(II) cation is coordinated by six N atoms of the three bidentate chelating 1,10-phenanthroline ligands in a slightly distorted octa-hedral coordination geometry. The Ni-N bond lengths range from 2.074 (2) to 2.

Bis(1,10-phenanthroline-κN,N')(sulfato-O)copper(II) ethane-1,2-diol monosolvate.

In the title compound, [Cu(SO(4))(C(12)H(8)N(2))(2)]·C(2)H(6)O(2), the Cu(II) ion is five-coordinated in a distorted square-pyramidal manner by four N atoms from two chelating 1,10-phenanthroline (phen) ligands and one O atom from a monodentate sulfate anion. The four N atoms comprise a square and the one O atom the apex of a square pyramid. The two chelating N(2)C(2) groups are oriented at 71.

Bis(1,10-phenanthroline-κN,N')(sulfato-κO,O')cobalt(II) butane-2,3-diol monosolvate.

In the title compound, [Co(SO(4))(C(12)H(8)N(2))(2)]·C(4)H(10)O(2), the Co(2+) ion has a distorted octa-hedral coordination environment composed of four N atoms from two chelating 1,10-phenanthroline ligands and two O atoms from an O,O'-bidentate sulfate anion. The dihedral angle between the two chelating N(2)C(2) groups is 83.48 (1)°.

Poly[diaquabis(μ-4,4'-bipyridine-κ2N:N')bis(ethane-1,2-diol)di-μ-sulfato-dicopper(II)].

The title compound, [Cu(2)(SO(4))(2)(C(10)H(8)N(2))(2)(C(2)H(6)O(2))(2)(H(2)O)(2)](n), contains two crystallographically unique Cu(II) centres, each lying on a twofold axis and having a slightly distorted octahedral environment. One Cu(II) centre is coordinated by two bridging 4,4'-bipyridine (4,4'-bipy) ligands, two sulfate anions and two aqua ligands. The second is surrounded by two 4,4'-bipy N atoms and four O atoms, two from bridging sulfate anions and two from ethane-1,2-diol ligands.

Bis(1,10-phenanthroline-κN,N')(sulfato-κO,O')cadmium(II) propane-1,3-diol solvate.

In the title compound, [Cd(SO(4))(C(12)H(8)N(2))(2)]·C(3)H(8)O(2), the Cd(II) atom has a distorted octa-hedral coordination composed of four N atoms from two chelating 1,10-phenanthroline ligands and two O atoms from an O,O'-bidentate sulfate group. The two chelating NCCN groups subtend a dihedral angle of 82.21 (9)°.

Bis(1,10-phenanthroline-κN,N')(sulfato-κO,O')nickel(II) propane-1,3-diol solvate.

In the structure of the title compound, [Ni(SO(4))(C(12)H(8)N(2))(2)]·C(3)H(8)O(2), the Ni(II) ion (site symmetry 2) is six-coordinated in a distorted octa-hedral manner by four N atoms from two chelating 1,10-phenanthroline (phen) ligands and two O atoms from a bidentate sulfate ligand (2 symmetry). The dihedral angle between the two chelating NCCN groups is 80.9 (1)°.