Relevance of peripheral inflammation indexes in different collateral circulation for intracranial hemorrhage in acute anterior circulation ischemic stroke patients undergoing endovascular treatment.

Background: Asymptomatic intracranial hemorrhage (aICH) is common after endovascular thrombectomy (EVT). Collateral circulation could modify the association between aICH with functional outcome and we aimed to investigate the impact of systemic inflammation index on 3-month outcome under different collateral circulation.

Method: Consecutive patients undertaken EVT were enrolled and classified into non-intracranial hemorrhage (non-ICH), aICH and symptomatic intracranial hemorrhage (sICH) groups according to the neurological status and National Institutes of Health Stroke Scale (NIHSS) changes within 72 hours after EVT.

Heme Oxygenase-1 Gene (GT)n Polymorphism Linked to Deep White Matter Hyperintensities, Not Periventricular Hyperintensities.

Background: Oxidative stress plays a principal role in the pathogenesis of white matter hyperintensities (WMHs). The induction of heme oxygenase-1 () gene in the brain represents 1 of the pivotal mechanisms to counteract the noxious effects of reactive oxygen species, and the transcriptional modulation of induction depends on the length of a GT-repeat (GT)n in the promoter region. We investigated whether the gene (GT)n polymorphism is associated with the risk of WMHs.

HS is involved in drought-mediated stomatal closure through PLDα1 in Arabidopsis.

PLDα1 promoted HS production by positively regulating the expression of LCD. Stomatal closure promoted by PLDα1 required the accumulation of HS under drought stress. Phospholipase Dα1 (PLDα1) acting as one of the signal enzymes can respond to drought stress.

Coping with Coronavirus Pandemic: Risk Perception Predicts Life Optimism.

Given that the coronavirus pandemic has become a severe concern worldwide, how can optimism be maintained during an outbreak of a collective pandemic? We propose that perceived control and negative affect could be potential explanatory factors for optimism in the face of a pandemic. In Study 1 ( = 599), through a large-scale cross-sectional design, we showed the indirect effect of risk perception on optimism through perceived control and negative affect with structural equation modeling. In Study 2 ( = 191), we manipulated perceived risk of the pandemic and determined that experiencing a high-risk pandemic psychologically led to decreased optimism.

Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth.

We reported previously that a hemiasterlin derivative BF65 is a potent anticancer agent that can inhibit microtubule assembly. Here we show that a more potent stereospecific diastereomer (R)(S)(S)-BF65 can synergize with an allosteric Akt inhibitor MK-2206 to suppress the growth of SKOV3 ovarian cancer cells with constitutively active Akt. (R)(S)(S)-BF65 induced mitotic arrest and MK-2206 caused G0/G1 arrest, while the combination of both induced simultaneous G0/G1 and G2/M cell cycle arrest.

Team innovation climate and knowledge sharing among healthcare managers: mediating effects of altruistic intentions.

Background: This paper aims to provide empirical evidence concerning the impact of team climate on knowledge sharing behavior and the mediating effects of individuals' altruistic intentions in the context of healthcare settings.

Methods: Questionnaire data were collected from 212 administrators employed at a medical center in Taiwan. Team climate was assessed by the Team Climate Inventory composed of four factors, participative safety, support for innovation, vision, and task orientation.