Publications by authors named "Kaili Xing"

Background: Patients with microvascular invasion (MVI)-positive hepatocellular carcinoma (HCC) have shown promising results with adjuvant hepatic arterial infusion chemotherapy (HAIC) with FOLFOX after curative resection. The authors aim to develop an imaging-derived biomarker to depict MVI-positive HCC patients more precisely and promote individualized treatment strategies of adjuvant HAIC.

Materials And Methods: Patients with MVI-positive HCC were identified from five academic centers and utilized for model development ( n =470).

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Smad4, a key mediator of the transforming growth factor-β signaling, is mutated or deleted in 20% of pancreatic ductal adenocarcinoma (PDAC) cancers and significantly affects cancer development. However, the effect of Smad4 loss on the immunogenicity and tumor immune microenvironment of PDAC is still unclear. Here, a surprising function of Smad4 in suppressing mouse PDAC tumor immunogenicity is identified.

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Article Synopsis
  • Traditional clinical variables are not enough to predict recurrence in patients with hepatocellular carcinoma (HCC) undergoing surgery due to tumor heterogeneity, but the novel vascular pattern known as vessels encapsulating tumor clusters (VETC) can indicate biological aggressiveness.
  • The study aimed to create a model using VETC and microvascular invasion (MVI) to provide personalized estimates of recurrence-free survival (RFS) for HCC patients based on data from 498 individuals from multiple centers in China.
  • Key findings showed that VETC, MVI, tumor number, and maximum tumor size were independent predictors of RFS, and a nomogram and risk score were developed to help estimate RFS more accurately compared to existing progn
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Immune checkpoint blockade has demonstrated remarkable efficacy in hepatocellular carcinoma (HCC) but is also commonly accompanied by immune-related adverse events (irAEs). However, the association between irAEs and antitumor efficacy in HCC patients remains unknown. All patients with HCC treated with anti-PD-1 antibodies from July 2018 to November 2019 were analyzed and divided into different groups according to their irAEs' status.

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Synaptophysin-like 1 (SYPL1) is a neuroendocrine-related protein. The role of SYPL1 in pancreatic ductal adenocarcinoma (PDAC) and the underlying molecular mechanism remain unclarified. Here, after analyzing five datasets (GSE15471, GSE16515, GSE28735, TCGA, and PACA-AU) and 78 PDAC patients from Sun Yat-sen University Cancer Center, we demonstrated that SYPL1 was upregulated in PDAC and that a high level of SYPL1 indicated poor prognosis.

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The prognosis of patients with post-operative recurrent intrahepatic cholangiocarcinoma (ICC) is at great variance. We aimed to propose a novel efficient prognostic nomogram in facilitating the risk stratification for post-operative recurrent ICC patients. From 2000 to 2016, a total of 237 post-operative recurrent ICC patients were enrolled in this study, and randomly divided into training ( = 178) and validation cohorts ( = 59) at a ratio of 3:1.

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Objective: Tumor associated macrophages (TAMs) promoted pancreatic ductal adenocarcinoma (PDAC) initiation and progression. In this study we aimed to evaluate CD10 expression by monocytes/macrophages and its clinical significance in PDAC.

Methods: Human CD14 peripheral blood monocytes were isolated and cultured for 6-7 days to differentiate into macrophages in vitro.

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There are few diagnostic tools that can be used to determine which patient with intrahepatic cholangiocarcinoma (ICC) can benefit from surgery actually, highlighting that the need for new preoperative stratification strategies. The aim of this study was to investigate the predictive values of preoperative biomarkers in survival analyses for patients with ICC after surgical resection. A total of 285 patients with ICC were retrospectively reviewed.

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