Publications by authors named "Kaili Hao"
Article Synopsis
- LINC01405 is a long non-coding RNA found to have high expression in muscle and is associated with various musculo-skeletal disorders.
- Researchers used the CRISPR/Cas9 gene-editing technology to create a knockout line of human embryonic stem cells that lack LINC01405.
- This new cell line retains its stem cell characteristics and ability to differentiate into all cell types, making it a valuable tool for studying LINC01405's role in the development of cardiac and skeletal muscle and related diseases.
Article Synopsis
- * Researchers created nanoparticles combining HA and alpha-ketoglutarate (αKG) to enhance stability and release in the knee joint, which showed improved pain relief, mobility, and less cartilage damage in mouse models of OA.
- * The study suggests these HA-αKG nanoparticles could be a promising treatment for OA, benefiting patients by promoting cartilage health and reducing stress in cartilage cells, potentially leading to quick clinical use.
Article Synopsis
- Glycogen Storage Disease type 4 (GSD4) is caused by a deficiency in glycogen branching enzyme 1 (GBE1) and affects multiple organs, leading to symptoms like hepatosplenomegaly and cardiac issues; the study identified two genetic variants in a patient.
- Researchers used CRISPR/Cas9 to edit induced pluripotent stem cells (iPSCs) from a healthy donor to create models that mimic the patient's GBE1 deficiency for better understanding of the disease.
- The results showed that the edited cells had lower GBE1 activity and displayed polyglucosan deposits similar to the patient's tissues, highlighting the potential of iPSC modeling in studying rare genetic disorders and assessing the impact
Objectives: Diabetes mellitus (DM) is correlated with poor clinical outcomes in spinal surgery. However, the effect of it on screw stabilization has not been investigated. The aim of this study was to evaluate the screw loosening rate and postoperative outcomes in diabetic patients and to identify potential risk factors associated with loosening.
View Article and Find Full Text PDFSuprachiasmatic nucleus (SCN) in mammals functions as the master circadian pacemaker that coordinates temporal organization of physiological processes with the environmental light/dark cycles. But the causative links between SCN and cardiovascular diseases, specifically the reparative responses after myocardial infarction (MI), remain largely unknown. In this study we disrupted mouse SCN function to investigate the role of SCN in cardiac dysfunction post-MI.
View Article and Find Full Text PDFHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) represent one of the most promising ways to treat cardiovascular diseases. High-purity cardiomyocytes (CM) from different cell sources could be obtained at present. However, the immature nature of these cardiomyocytes hinders its further clinical application.
View Article and Find Full Text PDFBackground: Endothelial cells are located in the inner lumen of blood and lymphatic vessels and exhibit the capacity to form new vessel branches from existing vessels through a process called angiogenesis. This process is energy intensive and tightly regulated. Glycolysis is the main energy source for angiogenesis.
View Article and Find Full Text PDF: As a hallmark of various heart diseases, cardiac fibrosis ultimately leads to end-stage heart failure. Anti-fibrosis is a potential therapeutic strategy for heart failure. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of heart diseases that promise to serve as therapeutic targets.
View Article and Find Full Text PDFMyocardial infarction (MI), with a major process of cardiomyocyte death, remains a leading cause of morbidity and mortality worldwide. To date, it has been shown that lncRNAs play important roles in cardiovascular pathology. However, the detailed studies on lncRNAs regulating cardiomyocyte death in myocardial infarction are still limited.
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