Publications by authors named "Kaili Che"

Purpose: To elucidate the structural-functional connectivity (SC-FC) coupling in white matter (WM) tracts in patients with major depressive disorder (MDD).

Methods: A total of 178 individuals diagnosed with MDD and 173 healthy controls (HCs) were recruited for this study. The Euclidean distance was calculated to assess SC-FC coupling.

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Article Synopsis
  • Traditional neuroimaging studies often focus on group analyses, missing out on individual differences in brain connectivity, which is crucial for understanding major depressive disorder (MDD).
  • This study aims to combine individualized functional and structural connectivity with machine learning to differentiate between people with MDD and healthy controls.
  • A total of 182 MDD patients and 157 healthy controls were involved, using advanced imaging techniques and statistical tests to assess connectivity differences, leading to the development of a support vector machine model for classification.
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  • Abnormalities in the connectivity between brain structures and their functions have been found in patients with major depressive disorder (MDD), but the differences across brain regions and their biological mechanisms remain unclear.
  • A study involving 182 MDD patients and 157 healthy controls assessed these connectivity differences using machine learning models, showing promising results for using these patterns as diagnostic biomarkers.
  • Findings indicated increased connectivity in certain brain networks among MDD patients, linked to neurotransmitter distributions and gene expression related to neuron function and signaling, suggesting potential avenues for targeted treatments.
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  • Major depressive disorder (MDD) shows significant alterations in white-matter functional connectivity (WM-IVFC) compared to healthy controls, highlighting a distinct neurobiological aspect of the disorder.
  • The study utilized functional MRI and gene expression analysis to identify WM-IVFC changes linked to various cognitive and behavioral functions, including sensorimotor processes and higher-order thinking.
  • The findings suggest that WM-IVFC not only helps distinguish MDD patients from healthy individuals but also effectively predicts the severity of depression and suicide risk, offering insights into MDD's clinical variability.
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Background: Previous studies have found qualitative structural and functional brain changes in major depressive disorder (MDD) patients. However, most studies ignored the complementarity of multisequence MRI neuroimaging features and cannot determine accurate biomarkers.

Purpose: To evaluate machine-learning models combined with multisequence MRI neuroimaging features to diagnose patients with MDD.

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Background: Characterization of the dynamics of functional brain network has gained increased attention in the study of depression. However, most studies have focused on single temporal dimension, while ignoring spatial dimensional information, hampering the discovery of validated biomarkers for depression.

Purpose: To integrate temporal and spatial functional MRI variability features of dynamic brain network in machine-learning techniques to distinguish patients with major depressive disorder (MDD) from healthy controls (HCs).

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  • Chronic coronary heart disease (CHD) is linked to a higher risk of cognitive impairment, and this study aims to uncover how changes in brain activity relate to this decline.
  • The research involved 71 CHD patients and 73 healthy controls, assessing cognitive functions using tests and measuring brain activity with techniques like regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuation (fALFF).
  • Findings showed that CHD patients had lower cognitive scores and reduced brain activity in specific regions, indicating that diminished brain function could mediate the impact of coronary artery plaque on cognitive decline.
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Background: Major depressive disorder (MDD) is an overbroad and heterogeneous diagnosis with no reliable or quantifiable markers. We aim to combine machine-learning techniques with the individual minimum spanning tree of the morphological brain network (MST-MBN) to determine whether the network properties can provide neuroimaging biomarkers to identify patients with MDD.

Method: Eight morphometric features of each region of interest (ROI) were extracted from 3D T1 structural images of 106 patients with MDD and 97 healthy controls.

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Background: Postpartum depression (PPD) is a common mood disorder with increasing incidence year by year. However, the dynamic changes in local neural activity of patients with PPD remain unclear. In this study, we utilized the dynamic amplitude of low-frequency fluctuation (dALFF) method to investigate the abnormal temporal variability of local neural activity and its potential correlation with clinical severity in PPD.

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Objectives: To develop and validate a Computed Tomography (CT) based radiomics nomogram for preoperative predicting of extrathyroidal extension (ETE) in papillary thyroid cancer (PTC) patients.

Methods: A total of 153 patients were randomly assigned to training and internal test sets (7:3). 46 patients were recruited to serve as an external test set.

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Objective: To investigate the application of computed tomography (CT)-based radiomics model for prediction of thyroid capsule invasion (TCI) in papillary thyroid carcinoma (PTC).

Methods: This retrospective study recruited 412 consecutive PTC patients from two independent institutions and randomly assigned to training (n=265), internal test (n=114) and external test (n=33) cohorts. Radiomics features were extracted from non-contrast (NC) and artery phase (AP) CT scans.

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Pregnancy leads to long-lasting changes in human brain structure; however, little is known regarding alterations in the topological organization of functional networks. In this study, we investigated the effect of pregnancy on human brain function networks. Resting-state fMRI data was collected from eighteen primiparous mothers and twenty-four nulliparous control women of similar age, education level and body mass index (BMI).

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Background: Postpartum depression (PPD) is a serious postpartum mental health problem worldwide. To date, minimal is known about the alteration of topographical organization in the brain structural covariance network of patients with PPD. This study investigates the brain structural covariance networks of patients with PPD by using graph theoretical analysis.

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Background: Postpartum depression (PPD) is a serious postpartum mental health problem worldwide. However, the cortical structural alterations in patients with PPD remain unclear. This study investigated the cortical structural alterations of PPD patients through multidimensional structural patterns and their potential correlations with clinical severity.

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Background And Purpose: Different atrophy of hippocampus subregions is a valuable indicator of patients with Alzheimer's disease (AD). To explore the relationship among the hippocampal subregions of patients with AD, altered gray matter structural covariance of hippocampal subregions in patients with AD was studied.

Materials And Methods: Participants were selected from the Open Access Series of Imaging Studies Database.

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The factors that determine the anatomical variations of the coronary venous system (CVS) are poorly understood. The objective of this study was to evaluate the anatomical variations of the CVS in patients with coronary artery calcification. 196 patients underwent non-contrast CT and coronary CT angiography using 256-slice CT.

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Background: To establish pharmacokinetic parameters and a radiomics model based on dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for predicting sentinel lymph node (SLN) metastasis in patients with breast cancer.

Methods: A total of 164 breast cancer patients confirmed by pathology were prospectively enrolled from December 2017 to May 2018, and underwent DCE-MRI before surgery. Pharmacokinetic parameters and radiomics features were derived from DCE-MRI data.

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To explore the changes of brain function and conduct clinical differential diagnosis based on support vector machine (SVM) in adolescent patients with depression. A total of 24 adolescent patients with depression according to CCMD-3 and DSM-5 and 23 gender, education level, body mass index, and age matched healthy controls were assessed with 17-item Hamilton Depression Rating Scale (HAMD). HAMD scores were requested from ≥17 of patients.

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Background: Postpartum depression (PPD) is a common mental disorder among women. However, the brain information flow alteration in patients with PPD remains unclear. This study investigated the brain information flow characteristics of patients with PPD and their value for clinical evaluation by using support vector regression (SVR).

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Objective: This study aims to establish and validate a radiomics nomogram based on contrast-enhanced spectral mammography (CESM) for prediction of axillary lymph node (ALN) metastasis in breast cancer.

Methods: This retrospective study included 394 patients with breast cancer who underwent CESM examination in two hospitals. The least absolute shrinkage and selection operator (LASSO) logistic regression was established for feature selection and utilized to construct radiomics signature.

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Abnormalities related to peripartum depression (PPD) have been detected in several brain regions through tasking-state functional magnetic resonance imaging (fMRI). In this study, we used the two markers of resting-state fMRI (rs-fMRI) to investigate changes in spontaneous neural activity of PPD and their correlation with depression severity. A total of 16 individuals with PPD were compared with 16 age- and education-matched healthy controls (HCs) by using rs-fMRI.

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Background: The torsion of normal adnexa is rare during pregnancy, especially in the third trimester. Nonspecific symptoms and signs as well as the limitations of ultrasound (US) make the diagnosis difficult, resulting in the loss of adnexa and fetal compromise. The magnetic resonance imaging (MRI) features of the torsion of normal adnexa are not classically described during pregnancy and only reported in a few cases.

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Objectives: To investigate the coronary venous system (CVS) and its spatial relationship with coronary arteries by using 256-slice computed tomography (CT).

Methods: One hundred one patients underwent coronary CT angiography by using a 256-slice CT. In each patient, the CVS and its spatial relationship with coronary arteries were analyzed.

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