Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1α/VEGF signaling axis.

Background: Circular RNAs (circRNAs) hold potential as diagnostic markers for colorectal cancer (CRC); however, their functional mechanisms remain incompletely elucidated. This work investigates the clinical implications of a unique set comprising six circRNAs derived from serum in CRC. Furthermore, we delve into the role of exosomal circ_0084043, originating from colorectal cancer-associated fibroblasts (CAFs), with a specific focus on its contribution to endothelial cell angiogenesis.