Publications by authors named "Kailang Mu"
Article Synopsis
- Lindl is a traditional medicine used by ethnic minorities, and this study aimed to identify the chemical components responsible for its antioxidant activity using advanced techniques like ultraperformance liquid chromatography (UPLC) and various assays.
- The study identified 32 common chemical peaks in Lindl and confirmed eight key antioxidant components, including proanthocyanidin B1 and epicatechin, through standard comparison.
- Important targets found in the research include EGFR and IL6, and relevant signaling pathways involved in diabetes and cancer were also explored, demonstrating the potential effectiveness of Lindl's components through molecular docking.
Article Synopsis
- This study investigates a plant-based hydrogel made from an extract of Thunbergia (B) to evaluate its effectiveness in wound healing and skin regeneration.
- The hydrogel, created using carbomer, glycerol, and triethanolamine, was tested in vitro for biocompatibility and its effects on cell functions such as proliferation, migration, and adhesion.
- Results showed that the hydrogel had good structure and stability, supported cell growth without toxicity, and significantly improved wound healing in animal models, indicating its potential as an innovative wound dressing.
Article Synopsis
- Hemorrhagic events lead to numerous deaths globally, creating a demand for effective hemostatic drugs; BSCE, derived from the orchid plant, shows promise in treating bleeding mice but needs further investigation for non-traumatic bleeding.
- In a study with 40 rats, BSCE was administered to assess its impact on various health metrics, including red blood cell count and lung tissue pathology, compared to a control group and a positive treatment group.
- Results indicated BSCE improved body weight, red blood cell levels, and lung tissue condition while positively influencing coagulation parameters and revealing potential biological pathways for hemostatic action via network pharmacology and molecular docking analysis.
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation leading to joint damage and disability, and this study aims to identify potential biomarkers and immune mechanisms for early diagnosis using machine learning and bioinformatics.
- Researchers analyzed public gene data, focusing on differentially expressed genes (DEGs) and applied functional enrichment analysis, utilizing various machine learning methods to narrow down key biomarkers associated with RA.
- 79 DEGs were identified, leading to the selection of 12 hub genes across multiple machine learning techniques, which were further validated for their expression and diagnostic significance in RA.
Article Synopsis
- * A total of 79 chemical constituents were identified, particularly phenylpropanoids, flavonoids, and alkaloids, with 13 active ingredients linked to nine key biological targets related to RA.
- * In laboratory tests, several components were shown to significantly inhibit inflammatory factor secretion in immune cells, indicating their potential as main active substances for RA treatment.
Ethnopharmacological Relevance: Traditional Chinese medicine and ethnic medicine together play an important value in the modern medicine system that is different from that of chemical drugs. Chinese medicine and ethnic medicine with hemostatic effect have unique advantages and development potential in the prevention and treatment of clinical hemorrhagic diseases, reflecting multi-component, multi-target and multi-pathway effects.
Aim Of The Study: In this paper, the active ingredients related to the hemostatic effect of traditional Chinese medicine and ethnic medicine are taken as the starting point, and the traditional Chinese medicine and ethnic medicine with traditional hemostatic purposes are reviewed, and the existing research progress on the active ingredients and their mechanism of action of these drugs is systematically expounded, aiming to provide theoretical reference for the development of traditional hemostatic drugs, the discovery of hemostatic active ingredients and the research of new hemostatic methods.