Publications by authors named "Kaikun Huang"
Background: The role of inflammation in the development of gestational diabetes mellitus (GDM) has recently become a focus of research. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), novel indices, reflect the body's chronic immune-inflammatory state. This study aimed to investigate the associations between the SII or SIRI and GDM.
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- The study investigates the link between levothyroxine (LT4) treatment and adverse pregnancy outcomes in pregnant women with elevated TSH levels (2.5-10.0 mIU/L) during the first trimester, focusing on those with varying TPOAb statuses.
- Using a retrospective cohort analysis of 4,370 pregnant women, the research employed propensity score matching to compare outcomes between those treated with LT4 and those who were not.
- Findings revealed that LT4 treatment significantly reduced the risk of pregnancy loss but increased the likelihood of small-for-gestational-age infants and preterm birth, particularly among TPOAb-positive women with high-normal TSH levels.
Background: Subclinical hypothyroidism (SCH) is linked to dyslipidaemia and adverse pregnancy outcomes. However, the impact of dyslipidaemia on the outcome of pregnancy in SCH is unclear.
Methods: We enrolled 36,256 pregnant women and evaluated their pregnancy outcomes.
Context: Previous studies on the relationship between thyroid gland function and the development of gestational diabetes mellitus (GDM) have reported different results, leading to the need for a cohort study design with a large sample size.
Objective: We aimed to investigate the relationship between thyroid function in early pregnancy and GDM.
Methods: This was a prospective cohort study based on the China Birth Cohort Study (CBCS), from February 2018 to December 2020.
Feeding practice is essential to growth and development of preterm toddlers. However, the relationship of feeding mode with gut microbiota and neurodevelopment outcomes of preterm toddlers has not been characterized fully. We conducted this cohort study to assess neurodevelopment outcomes and gut microbiota community structures of preterm toddlers who received either breast milk, formula or mixed feeding.
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