Publications by authors named "Kaijun Pan"
Article Synopsis
- Depressive disorders are a significant global issue linked to inflammation, particularly increased after the COVID-19 pandemic, with the JAK-STAT signaling pathway not yet fully explored in this context.
- A recent analysis suggests that the JAK inhibitor tofacitinib may have potential beyond immune diseases by possibly preventing mood disorders.
- Research indicates that the JAK-STAT pathway is activated in depressive mouse models, leading to inflammation and synaptic issues, but tofacitinib shows promise in reversing these effects, highlighting its potential for treating depression.
Simultaneous imaging of nitric oxide (NO) and its proximal proteins should facilitate the deconvolution of NO-protein interactions. While immunostaining is a primary assay to localize proteins in non-genetically manipulated samples, NO imaging probes with immunostaining-compatible signals remain unexplored. Herein, probe NOP-1 was developed with an NO-triggered proximal protein labeling capacity and fluorogenic signals.
View Article and Find Full Text PDFDiabetic patients receiving the antidiabetic drug metformin have been observed to exhibit a lower prevalence of anxiety disorders, yet the precise mechanism behind this phenomenon is unclear. In our study, we found that anxiety induces a region-specific reduction in AMPK activity in the medial prefrontal cortex (mPFC). Concurrently, transgenic mice with brain-specific AMPK knockout displayed abnormal anxiety-like behaviors.
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