Publications by authors named "Kaijian Xu"
Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages.
Arterioscler Thromb Vasc Biol
November 2023
Article Synopsis
- Current atherosclerosis treatments struggle to reverse advanced plaque buildup, with high amino acid levels from a Western diet causing mTORC1-autophagy defects in macrophages, worsening the condition.* -
- Research identified that the upregulation of Gpr137b-ps in atherosclerotic plaques impacts autophagy, with experiments on mice showing that reducing Gpr137b-ps enhances macrophage autophagy and reduces plaque lesions.* -
- Gpr137b-ps seems to inhibit the binding of HSC70 to G3BP, which in turn affects mTORC1 signaling, suggesting targeting this pathway could offer a new avenue for treating advanced atherosclerosis.*