Soft strain-insensitive bioelectronics featuring brittle materials.

Advancing electronics to interact with tissue necessitates meeting material constraints in electrochemical, electrical, and mechanical domains simultaneously. Clinical bioelectrodes with established electrochemical functionalities are rigid and mechanically mismatched with tissue. Whereas conductive materials with tissue-like softness and stretchability are demonstrated, when applied to electrochemically probe tissue, their performance is distorted by strain and corrosion.

[Influence of MRD Status in Newly Diagnosed MM Patients with VGPR and Above after Treatment on Clinical Prognosis].

Objective: To investigate the influence of MRD status in newly diagnosed MM patients with VGPR and above after treatment on clinical prognosis.

Methods: Clinical data of 210 newly diagnosed MM patients with VGPR and above after treatment in Fifth People's Hospital of Chendu city. from January 2010 to January 2018 were collected and retrospectively analyzed.

Very-low-dose decitabine treatment for patients with intermediate- or high-risk myelodysplastic syndrome: a retrospective analysis of thirteen cases.

Decitabine is a hypomethylating drug that is used to treat myelodysplastic syndrome (MDS) at a recommended dose and schedule (20 mg/m per day, for 5 consecutive days). However, due to its relatively high incidence of side effects and its effects on neoplastic cells, many studies have begun to explore the clinical application of a low dose of decitabine for treating MDS. In this retrospective study, we examined the effects of a very-low-dose decitabine schedule for treating MDS.

Structural design and environmental applications of electrospun nanofibers.

Nanofibers have attracted extensive attention and been applied in various fields due to their high aspect ratio, high specific surface area, flexibility, structural abundance, . The electrospinning method is one of the most promising and effective ways to produce nanofibers. The electrospun nanofibers-based films and membranes have already been demonstrated to possess small pore sizes, larges specific surface area, and can be grafted with different functionalities to adapt to various purposes.

Rapid degradation of 2,4-dichloronitrobenzene in single-chamber microbial electrolysis cell with pre-acclimated bioanode: A comprehensive assessment.

2,4-dichloronitrobenzene (DClNB) as a typical refractory pollutant, exists in multifarious industrial wastewater widely and poses a serious threat to the environment. An ion exchange membrane (IEM)-free microbial electrolysis cell (MEC) with pre-acclimated bioanode was built and evaluated systematically for treatment of DClNB containing wastewater. Results showed that compared with the non-acclimated or IEM-equipped MECs, the pre-acclimated IEM-free MECs had the best DClNB removal efficiency of 91.

[Therapeutic Efficacy of Qingre Jiedu and Huoxue Huayu Recipe in Prednisone-dependant Patients with Chronic Primary Immune Thrombocytopenic Purpura.].

Objectives: To observe the clinical efficacy of Qingre Jiedu and Huoxue Huayu Recipe on the prednisone-dependant patients with chronic primary immune thrombocytopenic purpura (CPITP).

Methods: Fifty prednisone-dependant CPITP patients were treated with Qingre Jiedu and Huoxue Huayu Recipe orally one dose a day,the dosage of prednisone for these patients was tapered according to the monitoring result of blood platelet count (BPC).The therapeutic efficacy in these patients was evaluated before and after Chinese medicine treatment over 4 weeks.

Tanshinone IIA inhibits acute promyelocytic leukemia cell proliferation and induces their apoptosis in vivo.

Tanshinone IIA (TanIIA) is a traditional Chinese agent and has been widely used for treatment of cardiovascular diseases. Our previous study has shown that TanIIA can induce the differentiation of acute promyelocytic leukemia (APL) cells by increasing C/EBPβ expression and induce APL cell apoptosis in vitro. In this study, we evaluated the activity of TanIIA against APL in vivo.

Tanshinone IIA in acute promyelocytic leukemia.

Introduction: The prognosis of acute promyelocytic leukemia (APL) has been significantly improved by the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). However, the utility of these drugs is limited by resistance to ATRA and the side effects of ATO. It has been reported that Tanshinone IIA (Tan IIA), a diterpene quinone isolated from Salvia Miltiorrhiza Bunge, induces apoptosis in the APL cell line, NB4.

C/EBPβ and CHOP participate in tanshinone IIA-induced differentiation and apoptosis of acute promyelocytic leukemia cells in vitro.

Our studies indicated that Tanshinone IIA (TanIIA), which is widely applied in the treatment of cardiovascular diseases with a rare occurrence of side effects, could promote APL cell differentiation and apoptosis. We found TanIIA induced the differentiation of NB4 and MR2 cells with elevated C/EBPβ and CHOP. When C/EBPβ was overexpressed in NB4 cells, the level of CD11b in the transfected cells was significantly elevated.