Publications by authors named "Kaihui Nan"

Currently, generalized therapy for traumatic optic neuropathy (TON) is lacking. Various strategies have been developed to protect and regenerate retinal ganglion cells (RGCs) after TON. Intravitreal injection of supplements has been approved as a promising approach, although serious concerns, such as low delivery efficacy and pain due to frequent injections, remain.

View Article and Find Full Text PDF
Article Synopsis
  • Optic nerve regeneration is difficult because of the limited ability of retinal ganglion cells (RGCs) to repair themselves and the harmful environment created after an injury.
  • Researchers created a bionic nanocomposite scaffold (GA@PDA) that helps RGCs regenerate by mimicking the optic nerve structure and reducing oxidative stress, which can harm RGCs.
  • In tests with rats, the GA@PDA scaffold improved RGC survival and promoted the growth of axons, indicating its potential for advancing treatments for optic nerve injuries.
View Article and Find Full Text PDF

In situ gelling eye drops of tacrolimus (FK506 Gel) were developed to address the formulation challenge of tacrolimus for anterior ocular inflammatory diseases. Both in silico and in vitro investigations were conducted to screen a suitable cyclodextrin species to increase the drug solubility. Guanosine was employed as the gelator and combined with inclusion complexes of tacrolimus in the presence of borate anions to obtain FK506 Gel, which gelated when came into contact with cations in tear fluid and led to the formation of a nanofibrous hydrogel.

View Article and Find Full Text PDF

Conventional hypotensive eye drops remain suboptimal for glaucoma management, primarily due to their limited intraocular bioavailability and the growing concern regarding ocular surface side effects. Therefore, there is an urgent need to develop innovative intraocular pressure (IOP)-lowering formulations that not only possess enhanced corneal penetration ability but also provide ocular surface protection. Herein, anti-oxidative mesoporous polydopamine nanoparticles (MPDA NPs) were explored as a nano-carrier for Brimonidine to address the above issues.

View Article and Find Full Text PDF

Dexamethasone (DEX) is used to treat ocular surface diseases. However, regulating DEX duration in tears while preventing its absorption into the anterior chamber is critical for balancing its therapy effects and the side effects. In this study, a novel magnetic nanoparticle (MNP)-micelle (MC) co-delivery system (MMDS) was developed.

View Article and Find Full Text PDF

Preventing bacterial infections is a crucial aspect of wound healing. There is an urgent need for multifunctional biomaterials without antibiotics to promote wound healing. In this study, we fabricated a guar gum (GG)-based nanocomposite hydrogel, termed GBTF, which exhibited photothermal antibacterial therapy for infected wound healing.

View Article and Find Full Text PDF

Dry eye disease (DED) is a multifactorial ocular surface disorder mutually promoted by reactive oxygen species (ROS) and ocular surface inflammation. NLRP3 is the key regulator for inducing ocular surface inflammation in DED. However, the mechanism by which ROS influences the bio-effects of NLRP3, and the consequent development of DED, largely remains elusive.

View Article and Find Full Text PDF

Retraction of 'Construction of a temperature-responsive terpolymer coating with recyclable bactericidal and self-cleaning antimicrobial properties' by Bailiang Wang , , 2016, , 1731-1741, https://doi.org/10.1039/C6BM00587J.

View Article and Find Full Text PDF

Retraction of 'A self-defensive antibacterial coating acting through the bacteria-triggered release of a hydrophobic antibiotic from layer-by-layer films' by Bailiang Wang , , 2017, , 1498-1506, https://doi.org/10.1039/C6TB02614A.

View Article and Find Full Text PDF

Expression of concern for ' and evaluation of xanthan gum-succinic anhydride hydrogels for the ionic strength-sensitive release of antibacterial agents' by Bailiang Wang , , 2016, , 1853-1861, https://doi.org/10.1039/C5TB02046H.

View Article and Find Full Text PDF

Expression of concern for 'Bacterial self-defense antibiotics release from organic-inorganic hybrid multilayer films for long-term anti-adhesion and biofilm inhibition properties' by Qingwen Xu, , 2017, , 19245-19254, https://doi.org/10.1039/C7NR07106J.

View Article and Find Full Text PDF
Article Synopsis
  • * Researchers developed TAT-Melatonin liposomes (TAT-MT-LIPs) to combat BAC-induced dry eye disease (BAC-DED) by reducing inflammation and preserving corneal cell integrity in rats.
  • * The study found that BAC triggers specific pathways leading to corneal cell death, but TAT-MT-LIPs effectively inhibited this damage by targeting mitochondrial DNA oxidation and inflammatory signaling.
View Article and Find Full Text PDF
Article Synopsis
  • Researchers are developing new multi-hydrophobic side chain polymers (MHCPs) based on lysine oligomers to improve the loading capacity of nanoparticles for hydrophobic drugs, addressing limitations in traditional amphiphilic copolymers.
  • These MHCPs form uniquely shaped nanoparticles that can effectively carry hydrophobic molecules and show significantly improved drug loading capability compared to previous methods.
  • The FK506-loaded nanoparticles demonstrate greater retention on the eye surface and show superior immunosuppressive effects compared to both free FK506 and commercial eye drops in preclinical tests.
View Article and Find Full Text PDF
Article Synopsis
  • Diquafosol tetrasodium (DQS) is a drug for dry eye treatment, but its clinical use has been limited due to a complex dosing schedule.
  • A new affinity hydrogel formulation (3% DQS Gel) was developed to allow for sustained release of DQS, improving its effectiveness for ocular surface drug delivery.
  • Studies showed that the 3% DQS Gel was more effective than other treatments in a mouse model of dry eye, suggesting this delivery method could benefit other similar hydrophilic drugs as well.
View Article and Find Full Text PDF

Dry eye disease (DED) is a widespread and frequently reported multifactorial ocular disease that not only causes ocular discomfort but also damages the cornea and conjunctiva. At present, topical administration is the most common treatment modality for DED. Due to the existence of multiple biological barriers, instilled drugs generally exhibit short action times and poor penetration on the ocular surface.

View Article and Find Full Text PDF

Oxidative stress is considered as a major factor causing retinal pigment epithelium (RPE) dysfunction and finally leading to retinal diseases such as age-related macular degeneration (AMD). Developing hydrogels for RPE cell delivery, especially those with antioxidant feature, is emerging as a promising approach for AMD treatment. Herein, a readily prepared antioxidant alginate-based hydrogel was developed to serve as a cytoprotective agent for RPE cells against oxidative damage.

View Article and Find Full Text PDF
Article Synopsis
  • Traumatic optic neuropathy (TON) leads to significant retinal ganglion cell (RGC) loss due to complex pathological mechanisms, with suggestive involvement of ferroptosis, an iron-dependent form of cell death.
  • Researchers used a rat model to test the delivery of hyaluronic acid (HA)-based deferoxamine (DFO) nanoparticles, aimed at reducing ferroptosis and protecting RGCs from TON-induced damage.
  • The study found that these DFO nanoparticles effectively concentrated around RGCs, enhanced DFO uptake, and inhibited key enzymes associated with cell death, presenting a potential new strategy for treating TON-related optic nerve injuries.
View Article and Find Full Text PDF

Purpose: To characterize biomechanical properties of genipin-crosslinked human dura mater as reinforcing material for posterior scleral reinforcement (PSR) and to compare it with crosslinked human sclera.

Methods: Donor dura mater and sclera were crosslinked in the same optimized genipin solution. Resistance to enzyme degradation for both materials were investigated by exposing the materials to accelerated enzyme degrading.

View Article and Find Full Text PDF

Traumatic optic neuropathy (TON) describes an injury to the optic nerve following either blunt or penetrating trauma, and remains an important cause of vision loss. No generalized treatment of TON has been established so far to restore the injured optic nerve. We developed an adherent drug-encapsulated bi-layered depot (DBP) as a dual drug vehicle for local treatment to protect the residual retinal ganglion cells (RGCs) and regenerate axons following optic nerve damage.

View Article and Find Full Text PDF

Purpose: To investigate effects of intravitreal anti-VEGF in combination therapy with sub-Tenon triamcinolone acetonide (STA) injection for uveitic macular edema (UME).

Design: A single-center, retrospective cohort study.

Methods: The medical records were obtained for 65 eyes of 65 patients with UME.

View Article and Find Full Text PDF

To deal with the complex tumor microenvironment (TME), chemodynamic therapy (CDT) has been developed, which uses nanocatalysts simulating peroxidase to convert high concentration hydrogen peroxide (HO) into highly toxic hydroxyl radicals (˙OH) and effectively kills tumor cells. Due to the low catalytic activity of traditional nanocatalysts, the present CDT treatment has to be combined with other anti-tumor therapies, which increases the complexity and uncertainty of the treatment. Thus, developing new nanocatalysts with stable and high enzymatic activity is the key point to CDT treatment.

View Article and Find Full Text PDF

In adult mammals, only minimal regeneration of the optic nerve (ON) is possible. Both the low levels of intrinsic regeneration ability of retinal ganglion cells (RGCs) and the inhibitory glial environment of ON contribute to it. To explore the influence of these two factors on the extent of axon regeneration, two ON injury models were established.

View Article and Find Full Text PDF

Fluorometholone (FMT) is a frequently prescribed drug for the alleviation of dry eye. However, due to low aqueous solubility, it has been routinely used as an ophthalmic suspension, which is characterized by low bioavailability, inconvenience of administration, and difficulty in delivering accurate dose. Furthermore, the opaque appearance of the ophthalmic suspension is not desirable for optical purpose.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session6eqebbac0qe20j2mippnes5fthtn2ujt): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once