SOX11 as a prognostic biomarker linked to m6A modification and immune infiltration in renal clear cell carcinoma.

Background: The prognosis for patients with kidney renal clear cell carcinoma (KIRC) remains unfavorable, and the understanding of SRY-box transcription factor 11 (SOX11) in KIRC is still limited. The purpose of this paper is to explore the role of SOX11 in the prognosis of KIRC.

Methods: We analyzed SOX11 expression in KIRC and adjacent normal tissues using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.

A new method for scaling inlet flow waveform in hemodynamic analysis of aortic dissection.

Computational fluid dynamics (CFD) simulations have shown great potentials in cardiovascular disease diagnosis and postoperative assessment. Patient-specific and well-tuned boundary conditions are key to obtaining accurate and reliable hemodynamic results. However, CFD simulations are usually performed under non-patient-specific flow conditions due to the absence of in vivo flow and pressure measurements.

A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth.

Thrombosis is a complex biological process which involves many biochemical reactions and is influenced by blood flow. Various computational models have been developed to simulate natural thrombosis in diseases such as aortic dissection (AD), and device-induced thrombosis in blood-contacting biomedical devices. While most hemodynamics-based models consider the role of low shear stress in the initiation and growth of thrombus, they often ignore the effect of thrombus breakdown induced by elevated shear stress.

Hemodynamic parameters impact the stability of distal stent graft-induced new entry.

Stent graft-induced new entry tear (SINE) is a serious complication in aortic dissection patients caused by the stent-graft itself after thoracic endovascular aortic repair (TEVAR). The stability of SINE is a key indicator for the need and timing of reinterventions. This study aimed to understand the role of hemodynamics in SINE stability by means of computational fluid dynamics (CFD) analysis based on patient-specific anatomical information.

Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis.

Bladder urothelial carcinoma (BLCA) accounts for 95% of all cases of bladder cancer worldwide, with a high incidence and poor prognosis. Chromobox (CBX) proteins play a key role in numerous malignant tumors; however, the role of CBX in BLCA remains unknown. Herein, the present study found that, compared with in normal bladder tissues, the expression levels of CBX1, CBX2, CBX3, CBX4 and CBX8 were markedly increased in BLCA tissues, as determined by Tumor Immune Estimation Resource, UALCAN and ONCOMINE analyses, whereas CBX6 and CBX7 were decreased in BLCA tissues.

Modified anterior approach preserving Retzius space versus standard anterior approach robot-assisted radical prostatectomy: A matched-pair analysis.

Objective: To compare our initial perioperative and postoperative outcomes of the modified anterior approach (MA) with Retzius space preservation robot-assisted radical prostatectomy (RARP) with the standard anterior approach (SA) RARP.

Materials And Methods: A retrospective analysis was performed on 116 patients with RARP completed by the same surgeon between September 2019 and March 2022. They were divided into SA-RARP group (77 cases) and MA-RARP group (39 cases).

Self-Optimizing Effect in Lithium Storage of GeO Induced by Heterointerface Regulation.

Herein, a heterostructural hexagonal@tetragonal GeO (HT-GeO ) composite has been designed based on density functional theory (DFT) calculations and synthesized via an acidic-heating route dealt with rapid cooling, where the inner hexagonal GeO (H-GeO ) phase is covered by a porous layer of tetragonal GeO (T-GeO ) owing to HF etching. Interestingly, the HT-GeO electrode has a self-optimizing effect in lithium storage induced by heterointerface regulation, where the porous T-GeO layer on the surface of HT-GeO can act as not only a Li /electron conducting layer, but also a buffer layer, while the inner H-GeO phase can react preferentially with Li ions owing to lower intercalation energy, which is confirmed by operando XRD measurement contributing to thorough lithiation for HT-GeO . Moreover, the heterointerface can enhance the pseudocapacitance effect, which can boost the Li storage and accelerate the discharge-charge process.

[Biological activity and hydroxy safflor yellow A content of intermediates in preparation of Safflower Injection].

In order to investigate the effect of various production processes on the quality of Safflower Injection, the biological activities of the intermediates were evaluated by measuring activated partial thromboplastin time (APTT) and adenosine diphosphate (ADP) induced platelet aggregation in vitro. Intermediates were produced by key processes, such as extraction, concentration, twice alcohol precipitation, water sedimentation and two sterilizations during the production of Safflower Injection. The content of main chemical components in intermediates was determined by HPLC.

In Vitro Anticoagulant Activity and Active Components of Safflower Injection.

Safflower injection is well-known as a traditional Chinese medicine used to improve the blood circulation. In this study, seven safflower injection samples from different companies were evaluated for their in vitro anticoagulant activity by measuring their activated partial thromboplastin time (APTT) and prothrombin time (PT) against human plasma. The screening results suggested that the safflower injections exhibited a significant prolonging influence on APTT ( < 0.

Model-Assisted Control of Flow Front in Resin Transfer Molding Based on Real-Time Estimation of Permeability/Porosity Ratio.

Resin transfer molding (RTM) is a popular manufacturing technique that produces fiber reinforced polymer (FRP) composites. In this paper, a model-assisted flow front control system is developed based on real-time estimation of permeability/porosity ratio using the information acquired by a visualization system. In the proposed control system, a radial basis function (RBF) network meta-model is utilized to predict the position of the future flow front by inputting the injection pressure, the current position of flow front, and the estimated ratio.

[Enhanced electro-catalytic oxidation of dye wastewater with FePMo12 adopted catalyst].

Electrochemical oxidation degradation of azo dyes has become a widely used method in recent years. Iron phosphomolybdate (FePMo12) was synthesized with molybdophosphoric acid and ferric salt. Morphology and microstructure of catalyst were chararerized by IR spectrometry and X-ray diffraction.

[Clinical application of advanced percutaneous vertebroplasty in treating of senile osteoporotic vertebral compression fracture].

Objective: To compare the differences between advanced percutaneous vertebroplasty and routine percutaneous vertebroplasty,and evaluate the clinical application of advanced percutaneous vertebroplasty in treating senile osteoporotic vertebral compression fracture.

Methods: From January 2010 to January 2011,28 patients with senile osteoporotic vertebral compression fracture were concealed random allocated to advanced percutaneous vertebroplasty and routine percutaneous vertebroplasty group according to whether using advanced percutaneous pedicle puncture. Of them,there were 5 males and 23 females with an average age of (70.

[Enhanced electro-chemical oxidation of Acid Red 3R solution with phosphotungstic acid supported on gamma-Al2O3].

Supported phosphotungstic acid catalysts on gamma-Al2O3 (HPW/gamma-Al2O3) were prepared by solution impregnation and characterized by FTIR, XRD, TG-DTA and SEM. The heteropolyanion shows a Keggin structure. Electro-chemical oxidation of Acid Red 3R was investigated in the presence of HPW supported on gamma-Al2O3 as packing materials in the reactor.