Publications by authors named "Kaihe Xiang"
Article Synopsis
- Mastitis is a serious illness in cows that can make their milk unhealthy, and it's linked to a condition called subclinical ketosis, where the cow's body isn't working as well as it should.
- The study found that cows with subclinical ketosis had more bad cells in their milk and different bacteria in their stomach compared to healthy cows.
- Researchers believe that changing the bacteria in cows’ stomachs could help treat and prevent mastitis.
Background: Mastitis is an inflammatory response in the mammary gland that results in huge economic losses in the breeding industry. The aetiology of mastitis is complex, and the pathogenesis has not been fully elucidated. It is commonly believed that mastitis is induced by pathogen infection of the mammary gland and induces a local inflammatory response.
View Article and Find Full Text PDFArticle Synopsis
- Cows with mastitis showed unusual changes in their gut bacteria, which were linked to inflammation and signs of illness.
- When gut bacteria from these cows were given to mice, the mice developed symptoms of mastitis, pointing to a connection between gut health and mastitis.
- Treatments that improved gut health helped reduce mastitis symptoms in mice, suggesting that fixing gut bacteria might help prevent or treat mastitis in cows.
Article Synopsis
- Cows with mastitis have a problem in their gut bacteria, which is called gut dysbiosis, where harmful bacteria grow and good bacteria decrease.
- When researchers transferred gut bacteria from sick cows to healthy mice, it made the mice sick, showing how bad bacteria can move from the gut to other body parts like the mammary gland.
- A good bacteria called Roseburia helps protect against this sickness by making a substance that reduces inflammation and helps repair barriers in the body, but more research is needed to understand how this works in cows and humans.
Article Synopsis
- Subacute ruminal acidosis (SARA) is a metabolic disease in ruminants that initially shows no clear symptoms but can lead to serious inflammatory diseases like laminitis and mastitis.* -
- The gut microbiota, consisting of various microorganisms, plays a key role in overall health and can influence both metabolic and inflammatory diseases by affecting the body beyond the gut.* -
- This review explores how SARA may lead to a chronic inflammatory state by allowing harmful bacteria and their products to enter the bloodstream, which can then trigger inflammatory diseases in other organs.*
Ketosis, a common metabolic disorder in dairy cattle, occurs during early lactation and leads to higher concentrations of non-esterified fatty acids (NEFAs) and β-hydroxybutyrate (BHBA), and is generally believed to be caused by excessive negative energy balance (NEB). Propylene glycol (PG), a gluconeogenic precursor, has been proved to promote gluconeogenesis and alleviate NEB. Oral administration of PG is widely considered one of the most effective therapeutic options for treating ketosis.
View Article and Find Full Text PDFFormononetin (FOR), a natural flavonoid derived from , has been reported to have anti-inflammatory and anti-oxidative effects. However, its protective mechanism against mastitis is still unknown. Nuclear factor kappa-B (NF-κB) signaling pathway plays an important role in inflammation, especially mastitis.
View Article and Find Full Text PDF