Publications by authors named "Kaihao Lin"
Introduction: The gut microbiota composition and the expression profiles of microRNAs (miRNAs) in the brain tissue, cerebrospinal fluid, and blood of patients with Alzheimer's disease (AD) differ significantly from those with normal cognition function. The study aimed to initially explore the relationship between plasma exosomal microRNAs, gut microbiota, and cognitive impairment, providing insights into the pathogenesis and treatment of AD.
Methods: The study enrolled 8 participants with AD and 8 participants with normal cognition.
Background: To ensure workforce stability in China's healthcare system and maintain high-quality care, it is essential to comprehensively understand the interplay of factors contributing to turnover intention of healthcare workers. This study aims to examine the associations between potential factors and turnover intention in healthcare workers and explore the mediating effect of job satisfaction and work engagement in the association between them.
Methods: In this cross-sectional study, a random sample of 1060 healthcare workers working in 98 public medical institutions were recruited to rate their turnover intention in 2018 in Shenzhen, China.
Article Synopsis
- - A meta-analysis assessed the effectiveness of nine different serological tests for early detection of nasopharyngeal carcinoma (NPC), which is known for its late diagnosis and poor prognosis.
- - The research reviewed 70 studies involving nearly 12,000 NPC cases and over 34,000 control subjects, focusing on the sensitivity and specificity of the antibody panels related to Epstein-Barr Virus (EBV).
- - Results indicated that combinations of certain antibody tests, like EBNA1-IgA combined with VCA-IgA, showed the highest sensitivity and diagnostic odds ratios, suggesting they may be the most viable options for NPC screening.
Pulmonary Tuberculosis Notification Rate Within Shenzhen, China, 2010-2019: Spatial-Temporal Analysis.
JMIR Public Health Surveill
June 2024
Background: Pulmonary tuberculosis (PTB) is a chronic communicable disease of major public health and social concern. Although spatial-temporal analysis has been widely used to describe distribution characteristics and transmission patterns, few studies have revealed the changes in the small-scale clustering of PTB at the street level.
Objective: The aim of this study was to analyze the temporal and spatial distribution characteristics and clusters of PTB at the street level in the Shenzhen municipality of China to provide a reference for PTB prevention and control.
Background: Understanding factors associated with antiretroviral treatment (ART) adherence is crucial for ART success among people living with HIV (PLHIV) in the "test and treat" era. Multiple psychosocial factors tend to coexist and have a syndemic effect on ART adherence. We aimed to explore factors associated with ART adherence and the syndemic effect of multiple psychosocial factors on ART adherence among PLHIV newly starting ART in Guangdong Province, China.
View Article and Find Full Text PDFBackground: Condom use at last intercourse is an effective indicator for human immunodeficiency virus (HIV) prevention. To identify at-risk individuals and improve prevention strategies, this study explored factors associated with condomless sex at last intercourse in the last year and developed a risk estimation model to calculate the individual possibility of condomless sex among college students in Zhuhai, China.
Methods: A cross-sectional study was conducted among 1430 college students who had sex in the last year from six universities in Zhuhai.
Article Synopsis
- The study aims to analyze changes in systolic and diastolic blood pressure trends among adults in Shenzhen from 1997 to 2018, using a cross-sectional design.
- Data were gathered from over 26,000 residents aged 18-69 through cluster sampling in three specific years: 1997, 2009, and 2018.
- Findings showed significant increases in both systolic and diastolic blood pressure for males and females, with a marked rise in hypertension rates among males, while female rates remained stable; awareness and treatment rates for hypertension declined during this period.
Background And Aim: The prevalence of antibiotic resistance for Helicobacter pylori (H. pylori) has been increasing over the year, making it more difficult for traditional empirical therapy to successfully eradicate H. pylori.
View Article and Find Full Text PDFBackground: Intimate partner violence (IPV) has been a concern among men who have sex with men (MSM), but less attention has been paid to the factors associated with this population in China.
Aims: We investigated the prevalence of and factors associated with IPV victimhood among MSM in Guangzhou, China.
Methods: Men who have sex with men were recruited from May to November 2017, and data were collected using an anonymous electronic questionnaire.
Late testing and antiretroviral therapy (ART) prevailed among people living with HIV (PLHIV) and impacted the benefit of immediate ART. This study aimed to identify the benefit of the test-and-immediate-treat policy in China, the effect of immediate ART, and the influence of late testing and ART on the whole PLHIV in Guangdong Province, China. We designed two tendency analyses in aggregative form and two cohorts (surveillance and ART cohort) in individuals' perspectives based on the HIV/AIDS Comprehensive Response Information Management System.
View Article and Find Full Text PDFObjective: Hypertension (HTN) is an important public health issue worldwide, associated with the rapid economic development and urbanisation over the last decades. This is especially the case in Shenzhen, which has benefited greatly from the reform and opening-up policies. However, there is limited information on the epidemiology of HTN in this region.
View Article and Find Full Text PDFBackground: High-flow nasal cannula (HFNC) is a new type of oxygen therapy, but its application in surgery remains unclear, we tried to describe the application of HFNC in microlaryngoscopic surgery for the Chinese population.
Methods: Nineteen adults, American society of anesthesiology class (ASA) 1-2 patients with body mass index < 30 kg.m underwent microlaryngoscopic surgery using HFNC for airway management.
[Research progress in the mechanisms of sperm sex chromosome aneuploidy].
Zhonghua Nan Ke Xue
June 2021
During the spermatogenesis of fertile men, an incidental meiosis mistake could induce the generation of aneuploid sperm, which may further cause the aneuploidy of embryos, miscarriage and chromosome abnormality of the offspring. Sex chromosomes of sperm have a higher tendency to be aneuploid than autosomes, though the mechanisms of sperm sex chromosome aneuploidy are not yet thoroughly understood. It may be attributed to the fact that the synapsis of sex chromosomes is confined to the pseudoautosomal region and that only one subsequent crossover is formed there.
View Article and Find Full Text PDFIntroduction: HIV self-testing (HIVST) is a useful strategy to promote HIV testing among key populations. This study aimed to understand HIV testing behaviours among men who have sex with men (MSM) and specifically how HIVST was used during the coronavirus disease 2019 (COVID-19) measures in China when access to facility-based testing was limited.
Methods: An online cross-sectional study was conducted to recruit men who have sex with men (MSM) in China from May to June of 2020, a period when COVID-19 measures were easing.
Introduction: A high proportion of people living with HIV (PLHIV) present for care with advanced HIV disease (AHD), which is detrimental to "90-90-90" targets to end AIDS by 2030. This study aimed to explore the prevalence of and factors related to AHD among newly diagnosed PLHIV in Guangdong Province, China.
Methods: Newly diagnosed PLHIV were recruited from six cities in Guangdong Province from May 2018 to June 2019.