Publications by authors named "Kaihang Luo"
Purpose: This study aims to evaluate the accuracy and safety of C1 lateral mass and upper cervical pedicle screw placement assisted by the TiRobot II system.
Methods: Ten patients who underwent cervical spine surgery assisted by the TiRobot II system were included. Screw accuracy was assessed using the Gertzbein-Robbins scale and by comparing the final screw positions with pre-planned trajectories.
Background: Although recent observational studies and clinical trials have indicated a strong association between the gut microbiota and spinal stenosis diseases, the causal relationship between them remains unclear.
Methods: Based on large-scale genome-wide association studies, we employed two-sample Mendelian randomization (MR) to analyse the causal relationships between the gut microbiota (GM) and 3 spinal stenosis diseases: adolescent idiopathic scoliosis (AIS), lumbar spondylolisthesis (LS), and spinal stenosis (SS). MR analysis was performed using the inverse variance weighting (IVW) method as the primary approach, supplemented by MR‒Egger regression, weighted median, and weighted mode analyses.
Active pulmonary tuberculosis (PTB) poses challenges in rapid diagnosis within complex clinical conditions. Given the close association between neutrophils and tuberculosis, we explored differentially expressed long non-coding RNAs (lncRNAs) in neutrophils as potential molecular markers for diagnosing active PTB. We employed a gene microarray to screen for lncRNA alterations in neutrophil samples from three patients with active PTB and three healthy controls.
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- Acute lung injury (ALI), which can lead to severe respiratory issues, is influenced by factors like lipopolysaccharides (LPS) and involves an important gene called WWOX, known to respond to environmental stress.
- Research shows that LPS reduces WWOX expression and the autophagy marker MAP1LC3B in lung cells, indicating a potential link to ALI development.
- Overexpressing WWOX increases autophagy and mitigates inflammatory responses in ALI models, suggesting it may protect against ALI through its interactions with the mTOR-ULK1 signaling pathway.