Assembly, network and functional compensation of specialists and generalists in poplar rhizosphere under salt stress.

Salinity is a major challenge for plant growth, but Populus euphratica, a species native to desert regions, has a remarkable ability to tolerate salt stress. This study aimed to explore how salinity affects the rhizosphere microbiome of P. euphratica, focusing on diversity patterns, assembly mechanisms, network characterization, and the functional roles of specialists and generalists under salt stress conditions.

High-power ultraflat broadband supercontinuum generation in fluorotellurite fiber pumped by a dual-wavelength femtosecond laser.

In this Letter, we report an ultraflat high-power supercontinuum (SC) based on a low-loss short-length fluorotellurite fiber. A novel high-peak power dual-Raman soliton femtosecond laser is used as a pump source, which effectively extends the mid-infrared SC spectral range and enhances the flatness of the SC. Finally, we obtained a 10.

Lasing at 2.1 µm pumped by a simultaneous-gain clad laser.

We obtained lasers based on the simultaneous-gain clad pump laser in a fluorotellurite fiber. Using a secondary suction method, we prepared a fluorotellurite double-clad preform with a Ho-doped core surrounded by a Tm-doped inner cladding, which we then drew into fibers. Tm ions generate a 1.

Recognition of TaeKwonDo kicking techniques based on accelerometer sensors.

TaeKwonDo (TKD) is a worldwide sport in both competitive among athletes and physical exercise among the public scenarios. Measuring TKD kicks have been studied a lot in a laboratory setting but rarely in a free-living situation. Machine learning algorithm combined with accelerometer data was used to study some martial art styles, e.

Generation of sub-150 fs, 10 W-class, pedestal-free 2.07 µm ultrashort pulses using a cascade compression system.

We report high-power pedestal-free ultrashort pulses in a cascade compression system. In the self-compression stage, the 2 µm ultrashort pulses with 123 fs duration and up to 21.7 W output power were obtained in a 0.

Design, synthesis, and activity evaluation of 2-iminobenzimidazoles as c-Myc inhibitors for treating multiple myeloma.

Multiple myeloma (MM) is a plasma cell malignancy that remains incurable and poses a significant threat to global public health. The multifunctional transcription factor c-Myc plays a crucial role in various cellular processes and is closely associated with MM progression. As part of the basic-helix-loop-helix-leucine zipper (bHLHZip) family, c-Myc forms heterodimers with its obligate partner Max, binds to the Enhancer-box (E-box) of DNA, and ultimately co-regulates gene expression.

High-power tunable Raman soliton generation in large core diameter passive fibers via a precise fundamental-mode matching technique.

We demonstrate tunable high-power, high-energy Raman solitons with the range of 1.9-2.3 µm in large mode area (LMA) fibers and an optimized fundamental-mode matching technique for coupling LMA silica fibers.

Investigation of the Mechanical Properties of Iron Tailings Concrete Subjected to Dry-Wet Cycle and Negative Temperature.

This research investigates the effects of iron tailings content on the mechanical properties and durability of concrete under dry-wet cycling and negative temperature conditions (-10 °C), where iron tailings replace river sand at rates of 0%, 10%, 20%, and 30%. A variety of tests were conducted on the iron tailings concrete, including compressive strength, flexural strength, splitting tensile strength, mass loss, and relative dynamic modulus, and its pore characteristics were analyzed using low-field nuclear magnetic resonance (NMR) experiments. The results reveal that when 20% of the river sand was replaced with iron tailings, the concrete achieved optimal splitting strength, compressive strength, and flexural strength at 28 days, improving by 0.

Disentangling leaf-microbiome interactions in by network mapping.

The leaf microbiota plays a key role in plant development, but a detailed mechanism of microbe-plant relationships remains elusive. Many genome-wide association studies (GWAS) have begun to map leaf microbes, but few have systematically characterized the genetics of how microbes act and interact. Previously, we integrated behavioral ecology and game theory to define four types of microbial interactions - mutualism, antagonism, aggression, and altruism, in a microbial community assembly.

Deciphering the diversity patterns and community assembly of rare and abundant bacterial communities in a wetland system.

Water microorganisms that have distinct contributions to community dynamics, including many rare taxa and few abundant taxa, are crucial to the wetland ecosystem functions. In this study, we comprehensively investigated the diversity patterns and assembly processes of rare and abundant taxa to strengthen our understanding of ecosystem function and diversity in a wetland system. The results showed that TN and NH-N were the most significant factors affecting the community structure in this wetland.

Comparative analysis of compound NSC13728 as Omomyc homodimer stabilizer by molecular dynamics simulation and MM/GBSA free energy calculation.

Myc is a master transcriptional regulator that controls almost all cellular processes, whose function is dependent on dimerization with its obligate partner Max. Stabilization of Max homodimer by small molecules (such as compound NSC13728) has proven an effective way to reduce the availability of Myc-Max dimer. Omomyc, a peptide inhibitor of Myc, is able to form Omomyc homodimer, which can competitively inhibit the binding of Myc-Max to the E-box of DNA.

Computational Insights Into the Effects of the R190K and N121Q Mutations on the SARS-CoV-2 Spike Complex With Biliverdin.

The SARS-CoV-2 spike has been regarded as the main target of antibody design against COVID-19. Two single-site mutations, R190K and N121Q, were deemed to weaken the binding affinity of biliverdin although the underlying molecular mechanism is still unknown. Meanwhile, the effect of the two mutations on the conformational changes of "lip" and "gate" loops was also elusive.

Silica-supported near-infrared carbon dots and bicarbonate nanoplatform for triple synergistic sterilization and wound healing promotion therapy.

Widespread bacterial infection and the emergence of antibiotic resistance exhibit an increasing threat to public health. Additionally, chronic wounds caused by bacterial infection have become a major challenge and threat in medical. Therefore, it is of great significance to explore effective and safe nanomaterials which possess antibacterial and wound healing promotion performance.

Transcriptional differentiation driving Cucumis sativus-Botrytis cinerea interactions based on the Skellam model and Bayesian networks.

Robust statistical tools such as the Skellam model and Bayesian networks can capture the count properties of transcriptome sequencing data and clusters of genes among treatments, thereby improving our knowledge of gene functions and networks. In this study, we successfully implemented a model to analyze a transcriptome dataset of Cucumis sativus and Botrytis cinerea before and after their interaction. First, 4200 differentially expressed genes (DEGs) from C.

Design, Synthesis and Pharmacological Evaluation of Naphthofuran Derivatives as Potent SIRT1 Activators.

Diabetic nephropathy (DN) is one of the most important medical complications in diabetic patients, which is an essential cause of end-stage renal disease in diabetic patients and still lacks effective medicines. Silent information regulator 1 (SIRT1) is closely related to the occurrence and development of DN. Activation of SIRT1 could significantly improve the symptoms of DN, while the activities of SIRT1 activators need to be further improved.

Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study.

Based on the up-regulation of the proviral integration site of the Moloney murine leukemia virus (Pim) kinase family (Pim1, 2, and 3) observed in several types of leukemias and lymphomas, the development of pan-Pim inhibitors is an attractive therapeutic strategy. While only PIM447 and AZD1208 have entered the clinical stages. To elucidate the interaction mechanisms of three Pim kinases with PIM447 and AZD1208, six Pim/ligand systems were studied by homology modeling, molecular docking, molecular dynamics (MD) simulation and molecular mechanics/generalized Born surface area (MM/GBSA) binding free energy calculation.