Publications by authors named "Kaifei Wagn"
Opt Express
February 2024
Article Synopsis
- Misfolding of amyloid proteins leads to neurodegeneration and the development of conformational diseases, but effective detection methods have been lacking.
- A novel metasurface-based biosensor has been proposed to characterize protein conformations using engineered complementary split ring resonators (cSRR) that enhance detection in both near-infrared (NIR) and mid-infrared (MIR) spectra.
- This biosensor offers sensitive detection of changes in the biolayer's refractive index and thickness in the NIR, and identifies specific molecular conformations in the MIR by recognizing unique spectral bands, aiding in the understanding of protein misfolding at the molecular level.
