Quercetin inhibits oligodendrocytes ferroptosis by blocking NCOA4-mediated ferritinophagy.

Ferritinophagy is a specific type of autophagy that maintains intracellular iron metabolic homeostasis by targeting ferritin, one of the major forms of iron storage in the human body. Previous research has demonstrated that quercetin prevents the ferroptosis of oligodendrocyte progenitor cells (OPCs) by inhibiting the Id2/transferrin pathway. Given the ability of quercetin to suppress autophagy in spinal cord injury (SCI), this study aimed to investigate whether quercetin prevents ferroptosis in an autophagy-dependent manner.