Synergistic Remediation of Cadmium Pollution in Saline-Alkali Soil by Hydrogel and .

The cadmium (Cd) in saline-alkali soil poses a serious threat to the ecological environment and human health. , as a hyperaccumulator plant, can remediate Cd in saline-alkali soil, but the efficiency of phytoremediation is low. To improve the remediation effect of Cd pollution in saline-alkali soil, this study for the first time uses the synergy of hydrogel and for the remediation of Cd in saline-alkali soil.

METTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell.

The development and homeostasis of intestinal epithelium are mediated by actively proliferating Lgr5+ stem cells, which possess a remarkable self-renewal and differentiation capacity. Recently, our study demonstrated that m6A methylation was essential for the survival of colonic stem cells. Here, we show that METTL3 expression is downregulated in the colon mucosa in ulcerative colitis (UC) patients and strongly associated with the differentiation and maturation of goblet cells during inflammation.

Belimumab versus telitacicept in sequential treatment after rituximab for refractory lupus nephritis: a real-world multicentre study.

Objective: Both belimumab and telitacicept are recognised blockers for B lymphocyte activation, both of which have been approved as add-on therapies for SLE in China. The aim of this study is to compare the efficacy of rituximab (RTX) followed by belimumab or telitacicept in a real-world cohort.

Methods: A total of 49 refractory lupus nephritis patients were enrolled from four independent centres, subsequently categorised into two treatment groups: belimumab group (n=35) and telitacicept group (n=14) based on their treatment following RTX.

Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors.

Background: Tumor cells can drive the senescence of effector T cells by unbalancing their lipid metabolism, thereby limiting adoptive T cell therapy and contributing to tumor immune evasion. Our objective is to provide a feasible strategy for enhancing T cell treatment efficacy against solid tumors.

Methods: In this study, liposomal arachidonyl trifluoromethyl ketone (ATK) was anchored onto the adoptive T cell surface via bioorthogonal reactions, aiming to specifically inhibit the group IVA cytosolic phospholipase Aα (cPLAα), a key enzyme facilitating phospholipid metabolism and senescent state of T cells.

Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression.

Background: The E3 ubiquitin ligase murine double minute 2 (MDM2) binds the p53 transcriptional activation domain and acts as a potent inhibitor of pathway, one of the three most crucial oncogenic pathways in urothelial carcinoma (UC). However, the clinical significance and impact on tumor immune contexture of amplification in UC remain unclear.

Methods: This study analyzed 240 patients with UC with matched clinical annotations from two local cohorts (ZSHS cohort and FUSCC cohort).

CREB3L1 facilitates pancreatic tumor progression and reprograms intratumoral tumor-associated macrophages to shape an immunotherapy-resistance microenvironment.

Background: To date, a growing body of evidence suggests that unfolded protein response (UPR) sensors play a vital role in carcinogenesis. However, it remains unclear whether they are involved in pancreatic ductal adenocarcinoma (PDAC) and how they relate to clinical outcomes. This study aims to investigate the biological function and mechanism of how a novel UPR sensor, CREB3L1 works in PDAC and further evaluate its clinical application prospect.

Using Discrete Choice Experiments to Measure the Preferences of Older People for Home Care Services in China.

The global aging demographic trend has led to an increased demand for home care services among older people. We measured the preferences and willingness to pay (WTP) of older adults in China for home care services using a discrete choice experiment (DCE) design. A total of 496 valid responses from older adults were included.

Spatiotemporal crash outliers are also noteworthy: evidence from 13 years of pedestrian-vehicle crashes in North Carolina.

Introduction: Previous research usually focused on high-frequency crash clusters (surrounded by high-frequency crashes), which overlooked outlier locations where high-frequency crashes were surrounded by low-frequency crashes. Neglecting spatiotemporal outliers might overlook critical factors for safety improvements.

Methods: Using pedestrian-vehicle crash data in North Carolina from 2007 to 2019, this study proposes an enhanced spatiotemporal analysis framework (combined with Approximate Nearest Neighbour and the Global Moran I index) to distinguish spatiotemporal crash outliers from aggregated/dispersed patterns.

Tract-specific white matter hyperintensities and neuropsychiatric syndromes: a multicentre memory clinic study.

Background: White matter hyperintensities (WMH) have been implicated in the pathogenesis of neuropsychiatric symptoms of dementia but the functional significance of WMH in specific white matter (WM) tracts is unclear. We investigate whether WMH burden within major WM fibre classes and individual WM tracts are differentially associated with different neuropsychiatric syndromes in a large multicentre study.

Method: Neuroimaging and neuropsychiatric data of seven memory clinic cohorts through the Meta VCI Map consortium were harmonised.

ALKBH5 promotes autophagy and progression by mediating m6A methylation of lncRNA UBOX5-AS1 in endometriosis.

Long noncoding RNA (lncRNA) and N6-methyladenosine (m6A) methylation modification have recently been suggested as potential functional modulators in ovarian endometriosis, however, the function and mechanism of m6A-modified lncRNA in ovarian endometriosis remain poorly understood. In this study, we demonstrated that lncRNA UBOX5-AS1 expression was significantly elevated in ovarian endometriosis tissue and primary ectopic endometrial stromal cells. The expression of lncRNA UBOX5-AS1, which has m6A modifications, was highly positively correlated with demethylase Alk B homologous protein 5 (ALKBH5) expression and autophagy.

Computational insights into the aggregation mechanism of human calcitonin.

Human calcitonin (hCT) is a peptide hormone that regulates calcium homeostasis, but its abnormal aggregation can disrupt physiological functions and increase the risk of medullary thyroid carcinoma. To elucidate the mechanisms underlying hCT aggregation, we investigated the self-assembly dynamics of hCT segments (hCT, hCT, and hCT) and the folding and dimerization of full-length hCT through microsecond atomistic discrete molecular dynamics (DMD) simulations. Our results revealed that hCT and hCT predominantly existed as isolated monomers with transient small-sized oligomers, indicating weak aggregation tendencies.

A novel composite hydrogel matrix carrier guar gum@2-oxopropanoic acid sodium salt@konjac glucomannan for sensitive response to active mold and yeast.

The synergistic effect of natural guar gum (GG), konjac gum (KGM) and sodium 2-oxopropanoic acid sodium (2-OAS) to designed a novel physical cross-linked three-dimensional network structure GG@2-OAS@KGM as a carrier of active microorganisms for mold and yeast sensitive detection. At the ratio of 6:2:2 (w/w/w), GG@2-OAS@KGM possessed a uniform porous structure. After treatment for 120 h, the hydrogel exhibits higher water holding capacity (WHC, 71.

Efficient stabilizing effect of low-dose zein/xanthan gum nanoparticles at the oil-water interface.

The inherent propensity for aggregation necessitates the use of high concentrations of protein-polysaccharide nanoparticles to achieve stable Pickering emulsions. This study employed xanthan gum (XG) to mitigate the pronounced aggregation of zein nanoparticles by structure construction, thereby enhancing the emulsifying efficiency of zein/XG (Z/XG) nanoparticles. The Z/XG nanoparticles displayed significantly enhanced dispersity, with the absolute ζ-potential increasing from 6.

Quaternized chitosan templated MoS nanohybrids for photothermal-enhanced synergistic antibacterial therapy.

Bacterial infections have become a fatal issue for human health. The excessive use of antibiotics leads to bacterial resistance. It is of great importance to develop alternate antimicrobial nanomaterials for effective antibacterial therapy.

The P-type ATPase gene AHA5 is involved in proanthocyanidins accumulation in Medicago truncatula.

Proanthocyanidins (PAs) are the second most abundant plant phenolic natural products. The proton membrane H-ATPase (AHA) is required for PA transportation in vacuoles, but it remains unclear which AHA gene(s) encode tonoplast proton pump in M. truncatula.

Inulin alleviates chronic ketamine-induced impairments in memory and prepulse inhibition by regulating the gut microbiota, inflammation, and kynurenine pathway.

Chronic ketamine administration causes cognitive impairments similar to those observed in schizophrenia. Growing evidence suggests that patients with schizophrenia show alterations in gut microbiota, which is associated with cognitive impairments. Inulin could regulate gut microbiota.

Genome-wide analysis of Class III peroxidase (PRX) family core genes and functional mechanism of GhPRXR1-A for seed development in Gossypium hirsutum.

Class III peroxidases (PRXs) play critical roles in plant growth and development by oxidizing various substrates with HO. Although many PRXs have been identified and their roles in biotic and abiotic stress responses have extensively investigated in plants. However, functional mechanisms of PRXs in seed development remain poorly understood.

ALKBH5 facilitates tumor progression via an m6A-YTHDC1-dependent mechanism in glioma.

N-methyladenosine (m6A) methylation, is a well-known epigenetic modification involved in various biological processes, including tumorigenesis. However, the role of AlkB homolog 5 (ALKBH5), a critical component of m6A modification, remains unclear in glioma. This study investigates the function of ALKBH5 in glioma progression and its potential as a therapeutic target.

Dual-responsive stem cell microspheres modified with BDNF for enhanced neural repair in diabetic erectile dysfunction.

We previously established an effective method to ameliorate erectile dysfunction (ED) using intracavernous injection (ICI) of mesenchymal stem cell (MSC) microspheres. However, the expression of a key neurotrophic factor, brain-derived neurotrophic factor (BDNF), was low in both MSCs and MSC microspheres, restricting the associated neural repair. Based on the hypoxia and oxidative stress microenvironments within cell spheroids and lesion areas, BDNF-expressing nanocomplexes that are dual-responsive to hypoxia and reactive oxygen species were designed to modify MSCs, achieving high BDNF expression in MSC spheroids.

Unveiling ADAMTS12: A Key Driver of Bladder Cancer Progression via COL3A1-Mediated Activation of the FAK/PI3K/AKT Signaling Pathway.

Bladder cancer (BCa) is a common and lethal disease characterized by high recurrence rates and limited treatment options. Understanding the molecular pathways of BCa progress is crucial for investigating more effective targeted therapies. While ADAMTS12 is known to contribute to cancer progression and treatment resistance, its prognostic significance and underlying mechanisms in BCa remain poorly understood.

Comprehensive metabolic profiling of three plants of Ardisia based on UPLC-QTOF-MS coupled with bioactivity assays.

Ethnopharmacological Relevance: Ardisia is a large genus of Primulaceae, 734 accepted species worldwide, and most species are used as ethnomedicines for the treatment of bruises, rheumatism, tuberculosis, and various inflammatory diseases. According to our previous ethnobotanical survey, Ardisia gigantifolia Stapf, Ardisia hanceana Mez (Da-luo-san), and Ardisia crenata Sims (Xiao-luo-san) are commonly used in folk medicine for the treatment of rheumatism. Among them, A.

Predicting Plaque Regression Based on Plaque Characteristics Identified by Optical Coherence Tomography: A Retrospective Study.

Background: Atherosclerosis is a lipid-driven, systemic immune-inflammatory disease characterized by the accumulation of plaque within the arterial walls. Plaque regression can occur following appropriate treatment interventions. Optical coherence tomography (OCT), a high-resolution imaging modality, is frequently employed to assess plaque morphology.

Correlation of SALL1 with CEUS Parameters and Immune Escape in Thyroid Carcinoma.

Background: Contrast-enhanced ultrasonography (CEUS) is widely used to diagnose thyroid carcinoma (TC), though its accuracy in differentiating malignant nodules is limited. We identified TC-associated differentially expressed genes (DEGs) and examined the impact of these genes, particularly SALL1, on immune escape mechanisms within TC cells.

Methods And Materials: DEG analysis was conducted on GSE65144 dataset to identify genes associated with TC.

Is there an association between eye-level greenness and childhood hypertension using street view? Findings from the Seven Northeastern Cities study in China.

There is a lack of evidence regarding associations of eye-level greenness exposure with blood pressure among children. We aimed to investigate the associations between eye-level greenness of different types and pediatric blood pressure in China. From 2012 to 2013, we recruited 9354 children aged between 5 and 17 years in northeast China.

Facile synthesis of flower-cluster ZIF nanocarriers: Performance in controlled release of thiamethoxam and insecticidal activity.

At present, it is highly important to develop nanopesticide, which can improve the effect of pesticides and reduce the risks of environmental. Zeolitic imidazolate framework (ZIF) is usually used as a nanocarrier of nanopesticide, which has a porous structure and stimuli-responsive properties. However, the drug loading performance and stability of ZIF are poor.