Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques.

Drug-induced liver injury (DILI) refers to drug-mediated damage to the structure and function of the liver, ranging from mild elevation of liver enzymes to severe hepatic insufficiency, and in some cases, progressing to liver failure. The mechanisms and clinical symptoms of DILI are diverse due to the varying combination of drugs, making clinical treatment and prevention complex. DILI has significant public health implications and is the primary reason for post-marketing drug withdrawals.

Liquid Foam Stabilized by a CO-Responsive Surfactant and Similarly Charged Cellulose Nanofibers for Reversibly Plugging in Porous Media.

CO foams are of great importance in oil recovery but challenging in some aspects like long-term stabilization and time-separated conflict. In this work, a stability-enhanced switchable foam was fabricated using bis-(2-hydroxyethoxy) olefine amine (BOA) and trace amounts (0.05 wt %) of cationic-modified cellulose nanofibers (CCNFs).

The perceived effectiveness and hidden inequity of postpandemic fiscal stimuli.

The world has committed trillions in fiscal expenditures to reboot the economy in the post–COVID-19 era. However, the effectiveness and the equity impacts of current fiscal stimuli are not fully understood. Using an extended adaptive regional input–output model, we assess the short-term impacts (2020 through 2022) of feasible stimuli on the global economy and the labor market.

Smart ultra-stable foams stabilized using cellulose nanocrystal (CNC) gels noncovalent bonding.

Smart ultra-stable foams stabilized by cellulose nanocrystal (CNC)-based gels were fabricated. The stabilization is ascribed to the dense films and three-dimensional networks at the interface and in the bulk induced by the charge shielding effect and electrostatic attraction between protonated bis(2-hydroxyethyl)oleylamine (BOA-H) micelles and negatively charged CNC colloids. The as-prepared foam could maintain its morphology without breaking or drainage for two months, showing high stability.

Prediction of Key Candidate Genes for Platinum Resistance in Ovarian Cancer.

Purpose: Ovarian cancer is one of the common malignant tumors of female reproductive organs, which seriously threatens the life and health of women. Resistance to chemotherapeutic drugs for ovarian cancer is the root cause of recurrence in most patients. The purpose of this study is to determine the differentially expressed genes of platinum resistance in ovarian cancer, and to screen out molecular targets and diagnostic markers that could be used to treat ovarian cancer platinum resistance.

Individualism and nationally determined contributions to climate change.

Ratcheting up the Nationally Determined Contributions (NDCs) to achieve the Paris Agreement goals requires a better understanding of the enablers and barriers behind NDC formulation. However, existing quantitative analyses on the drivers of NDCs from an anthropological perspective are elusive. This study proposes both a conceptual framework and empirical analysis of how cultural values link with the pledged NDCs.