Clinical Features and Laboratory Examination to Identify Severe Patients with COVID-19: A Systematic Review and Meta-Analysis.

Background: With the COVID-19 epidemic breakout in China, up to 25% of diagnosed cases are considered to be severe. To effectively predict the progression of COVID-19 via patients' clinical features at an early stage, the prevalence of these clinical factors and their relationships with severe illness were assessed.

Methods: In this study, electronic databases (PubMed, Embase, Web of Science, and Chinese database) were searched to obtain relevant studies, including information on severe patients.

Investigating Research Hotspots and Publication Trends of Spinal Stenosis: A Bibliometric Analysis During 2000-2018.

Spinal stenosis is a common disease affecting the elderly that is present in a various forms. Its high incidence forces researchers to pay more attention and offer countermeasures. We used the Web of Science Core collection and PubMed database to obtain 5,606 scientific studies concerning spinal stenosis, and the number of publications maintained a roughly increasing trend from 108 in 2000 to 512 in 2018, only declining in 2011.

A 10-year bibliometric analysis of osteosarcoma and cure from 2010 to 2019.

Background: In recent decades, the 5-year survival rate of osteosarcoma remains poor, despite the variety of operations, and exploration of drug therapy has become the key to improvement. This study investigates the contribution of different aspects in osteosarcoma and cure, and predicts research hotspots to benefit future clinical outcomes.

Methods: The Web of Science and PubMed databases were queried to collect all relevant publications related to osteosarcoma and cure from 2009 to 2019.

Pyroptosis in Osteoblasts: A Novel Hypothesis Underlying the Pathogenesis of Osteoporosis.

Osteoporosis has become a worldwide disease characterized by a reduction in bone mineral density and the alteration of bone architecture leading to an increased risk of fragility fractures. And an increasing number of studies have indicated that osteoblasts undergo a large number of programmed death events by many different causes in osteoporosis and release NLRP3 and interleukin (e.g.

Fecal and Serum Metabolomic Signatures and Microbial Community Profiling of Postmenopausal Osteoporosis Mice Model.

Background: Multiple studies have shown that an imbalance in the intestinal microbiota is related to bone metabolism, but the role of the intestinal microbiota in postmenopausal osteoporosis remains to be elucidated. We explored the effect of the intestinal microbiota on osteoporosis.

Methods: We constructed a postmenopausal osteoporosis mouse model, and Micro CT was used to observe changes in bone structure.

Septin4 regulates endoplasmic reticulum stress and apoptosis in melatonin‑induced osteoblasts.

Idiopathic scoliosis (IS) is a spinal 3‑dimensional deformity with an unknown cause. Melatonin is secreted by the pineal body and contributes to the occurrence and progression of IS. In our previous preliminary study, it was reported that high concentrations of melatonin can induce osteoblast apoptosis, thus acting as an IS treatment, but the mechanism of action is unknown.

Protective Role of Melatonin Against Postmenopausal Bone Loss Enhancement of Citrate Secretion From Osteoblasts.

A negative correlation exists between the severity of osteoporosis and citrate levels in bone. Our previous research found that melatonin can significantly improve bone mass in mice with osteoporosis, but the underlying mechanism involving citrate remains unknown. Herein, we demonstrated that melatonin increased bone volume and citrate levels in ovariectomized osteoporosis mice.

COVID-19 will stimulate a new coronavirus research breakthrough: a 20-year bibliometric analysis.

Background: COVID-19 is currently rampant in China, causing unpredictable harm to humans. This study aimed to quantitatively and qualitatively investigate the research trends on coronaviruses using bibliometric analysis to identify new prevention strategies.

Methods: All relevant publications on coronaviruses were extracted from 2000-2020 from the Web of Science database.

The publication trends and hot spots of scoliosis research from 2009 to 2018: a 10-year bibliometric analysis.

Background: This study aims to quantitatively and qualitatively investigate the trends in scoliosis research and evaluate research hotspots using bibliometric analysis.

Methods: All relevant publications on scoliosis from the period from 2009 to 2018 were extracted from the Web of Science and PubMed databases. Publication trends were analyzed using an Online analysis platform of literature metrology, Bibliographic Item Co-occurrence Matrix Builder (BICOMB), and CiteSpace software.

Energy transfer in intermolecular collisions of polycyclic aromatic hydrocarbons with bath gases He and Ar.

Classical trajectory simulations of intermolecular collisions were performed for a series of polycyclic aromatic hydrocarbons interacting with the bath gases helium and argon for bath gas temperature from 300 to 2500 K. The phase-space average energy transferred per deactivating collision, ⟨∆E⟩, was obtained. The Buckingham pairwise intermolecular potentials were validated against high-level quantum chemistry calculations and used in the simulations.