Limbal stem cells carried by a four-dimensional -printed chitosan-based scaffold for corneal epithelium injury in diabetic rabbits.

Herein, we obtained and characterized deltaN p63- and adenosine triphosphate-binding cassette subfamily G member 2-expressing limbal stem cells (LSCs). Chitosan and carboxymethyl chitosan (CTH) were cross-linked to be an in situ thermosensitive hydrogel (ACH), which was printed through four-dimensional (4D) printing to obtain a porous carrier with uniform pore diameter (4D-CTH). Rabbits were injected with alloxan to induce diabetes mellitus (DM).

Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model.

Background: Tibial Cortex Transverse Transport (TTT) represents an innovative surgical method for treating lower extremity diabetic foot ulcers (DFUs), yet its underlying mechanisms remain elusive. Establishing an animal model that closely mirrors clinical scenarios is both critical and novel for elucidating the mechanisms of TTT.

Methods: We established a diabetic rat model with induced hindlimb ischemia to mimic the clinical manifestation of DFUs.

If we should remove internal fixation devices for rib fractures?

Background: Internal fixation for rib fractures has been widely carried out worldwide, and its surgical efficacy has been recognized. However, there is still controversy about whether implant materials need to be removed. At present, the research on this topic is still lacking at home and abroad.

Mastery of chest wall reconstruction with a titanium sternum-rib fixation system: a case series.

Background: Chest wall disease is a common disease in thoracic surgery. For most chest wall lesions, surgical resection is the mainstay of treatment. Reconstruction is indicated for a wide range of chest wall defects.

The Color Improvement of Underwater Images Based on Light Source and Detector.

As one of the most direct approaches to perceive the world, optical images can provide plenty of useful information for underwater applications. However, underwater images often present color deviation due to the light attenuation in the water, which reduces the efficiency and accuracy in underwater applications. To improve the color reproduction of underwater images, we proposed a method with adjusting the spectral component of the light source and the spectral response of the detector.

Smooth Surface Visual Imaging Method for Eliminating High Reflection Disturbance.

At present, visual imaging is widely applied for surface defects such as bumps and scratches in the manufacture of precise parts with a highly reflective surface. However, the high light reflection and halo disturbance as a result of the illumination in visual imaging exert a direct influence on the accuracy of defect detection. In this regard, the present paper develops an adaptive illumination method based on space-time modulation for a visual imaging system.

Antitumor effect of hyaluronic-acid-modified chitosan nanoparticles loaded with siRNA for targeted therapy for non-small cell lung cancer.

Nanoparticle (NP)-mediated targeted delivery of therapeutic genes or siRNAs to tumors has potential advantages. In this study, hyaluronic acid (HA)-modified chitosan nanoparticles (CS NPs-HA) loaded with cyanine 3 (Cy3)-labeled siRNA (sCS NPs-HA) were prepared and characterized. Human non-small cell lung cancer (NSCLC) A549 cells expressing receptor CD44 and tumor-bearing mice were used to evaluate the cytotoxic and antitumor effects of sCS NPs-HA in vitro and in vivo.

An in situ hydrogel based on carboxymethyl chitosan and sodium alginate dialdehyde for corneal wound healing after alkali burn.

There is currently no optimal scaffold for the transplantation of limbal stem cells (LSCs) to induce corneal reconstruction after corneal alkali burns. This study attempts to fabricate a novel in situ Alginate-Chitosan hydrogel (ACH) for LSCs transplantation. Sodium alginate dialdehyde (SAD), a biological crosslinker, was prepared by periodate-mediated sodium alginate oxidization.