YTHDF3-mediated FLCN/cPLA2 axis improves cardiac fibrosis via suppressing lysosomal function.

Cardiac fibrosis characterized by aberrant activation of cardiac fibroblasts impairs cardiac contractile and diastolic functions, inducing the progression of the disease towards its terminal phase, resulting in the onset of heart failure. Therefore, the inhibition of cardiac fibrosis has become a promising treatment for cardiac diseases. The ovarian follicle-stimulating hormone folliculin (FLCN) plays a significant role in various biological processes, such as lysosome function, mitochondrial synthesis, angiogenesis, ciliogenesis and autophagy.

Increased reactive astrocytes and NLRC4-mediated neuronal pyroptosis in advanced visual structures contralateral to the optic nerve crush eye in mice.

Currently, research on optic nerve injury predominantly focuses on the retina and optic nerve, but emerging evidence suggests that optic nerve injury also affects advanced visual structures like the superior colliculus (SC) and primary visual cortex (V1 region). However, the exact mechanisms have not been fully explored. This study aims to investigate the characteristics and mechanisms of pathology in the SC and V1 region after optic nerve crush (ONC) to deepen our understanding of the central mechanism of visual injury.

Situations and demands of central sterile supply department training on nursing interruptions.

Backgrounds: Central sterile supply department (CSSD) is an important department in the hospital. It can ensure successful sterilization and nosocomial infection control. CSSD staff are often interrupted during cleaning, disinfection, packaging, sterilization and distribution.

Current trends and hotspots of etiology of auditory neuropathy in the past 30 years: A bibliometric analysis.

Objective: To make an overview of global research trends in the etiology of auditory neuropathy (AN) over the past 30 years using a bibliometric approach.

Methods: Bibliometric analyses were conducted by GraphPad Prism 9.0, Citespace 6.

Fabrication of core-shell nanostructure via novel ligand-defect reassembly strategy for efficient photocatalytic hydrogen evolution and NO removal.

The core-shell structure often exhibits unique properties, resulting in superior physical and chemical performance distinct from individual component in the field of photocatalysis. However, traditional prepared methods such as template synthesis and layer-by-layer self-assembly are relatively complex. Therefore, it is necessary to explore an efficient and expedient approach.

Prevalence, Clinical Characteristics, and Relative Factors of Acquired Punctal Stenosis in Adult Allergic Conjunctivitis Patients.

Introduction: The objective of this study was to investigate the prevalence, characteristics, and risk factors of acquired punctal stenosis (APS) in adult patients with allergic conjunctivitis (AC).

Methods: This observational case series study included 210 adult AC patients at Zhongshan Ophthalmic Center. The demographic data were collected, and the ocular manifestations were assessed.

Insight into selenium vacancies enhanced CoSe/MoSe heterojunction nanosheets for hydrazine-assisted electrocatalytic water splitting.

The integration of interface engineering and vacancy engineering was a feasible way to develop highly efficient electrocatalysts toward water electrolysis. Herein, we designed CoSe/MoSe heterojunction nanosheets with abundant Se vacancies (V-CoSe/MoSe) for electrocatalytic water splitting. In the V-CoSe/MoSe electrocatalyst, the electrons more easily transferred from CoSe to MoSe, and interface engineering not only modulated the electronic structure, but also supplied more heterointerfaces and catalytic sites.

Construction of 2D/2D S-scheme BiMoO/Zn-TCPP heterojunction via in-situ self-assembly growth strategy to enhance interface effect for efficient photocatalytic hydrogen production.

Two-dimensional/two-dimensional (2D/2D) heterojunctions are considered to be an effective strategy for forming strong interface effects and facilitating photogenerated carrier separation. However, it is usually limited by the size mismatch of the materials, even at the expense of its redox capability. Herein, 2D/2D S-scheme heterojunction photocatalyst BiMoO/Zn-TCPP (BMO/ZTP) composed of 2D BiMoO and 2D Zn-TCPP (TCPP: tetrakis (4-carboxyphenyl) porphyrin) (MOFs) was constructed by in-situ self-assembly growth strategy.

Targeted metabolomic analysis of serum free fatty acids: Lipidomics disturbance in patients with superior limbic keratoconjunctivitis.

This study aimed to identify and quantify free fatty acids (FFAs), secretory phospholipase A2 group IIa (sPLA2-IIa) and cytosolic phospholipase A2 (cPLA2) in serum of superior limbic keratoconjunctivitis (SLK) patients and explored the association between FFAs, sPLA2-IIa and cPLA2 variations and SLK. Targeted metabolomic analysis of FFAs in serum was performed by gas chromatography tandem mass spectrometry (GC-MS/MS) analysis on 16 SLK patients (43.88 ± 7.

Corrigendum: Involvement of endoplasmic reticulum stress in trigeminal ganglion corneal neuron injury in dry eye disease.

[This corrects the article DOI: 10.3389/fnmol.2023.

Correlation between urinary rare earth elements and liver function in a Zhuang population aged 35-74 years in Nanning.

Background: Animal studies have shown that exposure to REEs can cause severe liver damage, but evidence from population studies is still lacking. Therefore, we investigated the relationship between REEs concentrations in urine and liver function in the population.

Methods: We conducted a cross-sectional study on 1024 participants in Nanning, China.

Clinical and genetic architecture of a large cohort with auditory neuropathy.

Auditory neuropathy (AN) is a unique type of language developmental disorder, with no precise rate of genetic contribution that has been deciphered in a large cohort. In a retrospective cohort of 311 patients with AN, pathogenic and likely pathogenic variants of 23 genes were identified in 98 patients (31.5% in 311 patients), and 14 genes were mutated in two or more patients.

Natural History of KCNQ4 p.G285S Related Hearing Loss, Construction of iPSC and Mouse Model.

Objective: KCNQ4 is one of the most common disease-causing genes involved in autosomal dominant non-syndromic hearing loss. We previously found that patients with KCNQ4 p.G285S exhibited a much more rapid deterioration in hearing loss than those with other KCNQ4 variants.

Modulating Electronic Structure by Etching Strategy to Construct NiSe /Ni Se Heterostructure for Urea-Assisted Hydrogen Evolution Reaction.

Exploring and developing novel strategies for constructing heterostructure electrocatalysts is still challenging for water electrolysis. Herein, a creative etching treatment strategy is adopted to construct NiSe /Ni Se heterostructure. The rich heterointerfaces between NiSe and Ni Se emerge strong electronic interaction, which easily induces the electron transfer from NiSe to Ni Se, and tunes the charge-state of NiSe and Ni Se.

Retrospective analyses of routine preoperative blood testing in a tertiary eye hospital: could Choosing Wisely work in China?

Aims: To explore the possibility of implementing Choosing Wisely on ocular patients in China by investigating the prevalence of abnormalities in routine preoperative blood tests (RPBTs) and its turnaround time (TAT).

Methods: Data from 102 542 ocular patients between January 2016 and December 2018, at Zhongshan Ophthalmic Center, were pooled from the laboratory information system. The test results were divided into normal and abnormal, including critical values.

Constructing abundant interfaces by decorating MoP quantum dots on CoP nanowires to induce electronic structure modulation for enhanced hydrogen evolution reaction.

Interface engineering is a method of enhancing catalytic activity while maintaining a material's surface properties. Thus, we explored the interface effect mechanism a hierarchical structure of MoP/CoP/CuP/CF. Remarkably, the heterostructure MoP/CoP/CuP/CF demonstrates an outstanding overpotential of 64.

Distributed observer-based finite-time control of moving target tracking for UAV formation.

This paper disseminated two formation control strategies for multiple unmanned aerial vehicles (multi-UAV) system of moving target tracking in a windy environment. The communication among UAVs is modeled by a directed graph. The first control strategy proposes a distributed dynamic error observer and a guidance law to make the system global uniform asymptotic stability when the wind disturbance is a known constant.

Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated atherosclerosis via suppressing YTHDF2-mediated mA modification of SIRT3 mRNA.

Ethnopharmacological Relevance: Fufang Zhenzhu TiaoZhi (FTZ), a Chinese medicinal decoction, has continuously been used to treat metabolic syndrome. Atherosclerosis is the main pathological basis of cardiovascular disease. The N6 methyladenosine (mA) modification is a highly dynamic and reversible process involving a variety of important biological processes.

Dual Atoms (Fe, F) Co-Doping Inducing Electronic Structure Modulation of NiO Hollow Flower-Spheres for Enhanced Oxygen Evolution/Sulfion Oxidation Reaction Performance.

Heteroatoms Fe, F co-doped NiO hollow spheres (Fe, F-NiO) are designed, which simultaneously integrate promoted thermodynamics by electronic structure modulation with boosted reaction kinetics by nano-architectonics. Benefiting from the electronic structure co-regulation of Ni sites by introducing Fe and F atoms in NiO , as the rate-determined step (RDS), the Gibbs free energy of OH* intermediates (ΔG ) for Fe, F-NiO catalyst is significantly decreased to 1.87 eV for oxygen evolution reaction (OER) compared with pristine NiO (2.

Recent advances in interface engineering of Fe/Co/Ni-based heterostructure electrocatalysts for water splitting.

Among various methods of developing hydrogen energy, electrocatalytic water splitting for hydrogen production is one of the approaches to achieve the goal of zero carbon emissions. It is of great significance to develop highly active and stable catalysts to improve the efficiency of hydrogen production. In recent years, the construction of nanoscale heterostructure electrocatalysts through interface engineering can not only overcome the shortcomings of single-component materials to effectively improve their electrocatalytic efficiency and stability but also adjust the intrinsic activity or design synergistic interfaces to improve catalytic performance.

Efficacy of sodium polyanethol sulfonate on herpes simplex virus-1 infection in vitro.

Unlabelled: Objective: To investigate the effect of sodium polyanethol sulfonate (SPS) on herpes simplex virus type 1 (HSV-1) infection in vitro.

Methods: Human corneal epithelial (HCE-T) cells and Vero cells were infected with HSV-1 [HSV-1 f strain, HSV-1f; HSV-1-H129 with green fluorescent protein (GFP) knock-in, HSV-1g]. SPS was added to the culture medium at various concentrations in time-of-addition assay.

Involvement of endoplasmic reticulum stress in trigeminal ganglion corneal neuron injury in dry eye disease.

Dry eye disease (DED) is a multifactorial disease with a high prevalence worldwide. Uncomfortable corneal sensations severely affect daily life in DED patients. Hence, corneal neuron injury is a vital pathogenesis in DED.

A20 functions as a negative regulator of the lipopolysaccharide-induced inflammation in corneal epithelial cells.

A20, also called TNFAIP3, is a crucial regulator of inflammation in various diseases but has not evidenced its function in the cornea. We aimed to evaluate the existence and the functions of A20 in human corneal epithelial (HCE-T) cells. After being treated with lipopolysaccharide (LPS) in different concentrations or at separate times, cells were collected to analyze A20 expressions.

3D Printed Gas Distributor for Enhanced Production of CaCO via Bubbling Carbonation.

Bubbling carbonation is the most widely used method for production of CaCO. A structure-controllable preparation of calcium carbonate with homogeneous crystallinity and narrow particle size distribution is generally required. In this work, a gas distributor is designed and fabricated by light-curing three-dimensional (3D) printing technology to optimize the pore size and distribution of the distributor.

Piezoresistive Pressure Sensor Based on a Conductive 3D Sponge Network for Motion Sensing and Human-Machine Interface.

Flexible sensors have attracted increasing attention owing to their important applications in human activity monitoring, medical diagnosis, and human-machine interaction. However, the rational design of low-cost sensors with desirable properties (e.g.