Molecular identification of three cytochrome P450 genes and their potential roles in insecticides tolerance in Grapholita molesta (Busck).

The oriental fruit moth, Grapholita molesta (Busck), is a significant pest of Rosaceae trees worldwide and has developed resistance to various insecticides. Cytochrome P450 play a major role in detoxification of resistance to insecticides in insects. In this study, we found that Piperonyl butoxide (PBO), which inhibits the P450 activity, synergized with abamectin, imidacloprid, and L-cyhalothrin, increasing mortality rates of G.