Publications by authors named "Kai-Yang Lv"
Background: Microskin autografts with conventional wrap and compression are used extensively in the treatment of skin and tissue defects. This comparative study aimed at investigation of the clinical application of negative pressure wound therapy (NPWT) in combination with microskin autografts for repair of acute and chronic wounds.
Methods: A prospective case-control study was performed from December 1, 2010-December 31, 2013 in Changhai Hospital, Shanghai.
Article Synopsis
- Smad3 is a key player in the signaling process for transforming growth factor β, which is involved in inflammation and immunity; its role in regulating iNOS expression during septic shock is not well understood.
- In experiments, Smad3 knockout (KO) mice showed higher mortality and more severe hypotension after being injected with lipopolysaccharide (LPS) compared to wild-type (WT) mice, indicating that the absence of Smad3 increases vulnerability to septic shock.
- Both KO and WT mice had increased levels of plasma nitrite and iNOS expression after LPS treatment, but KO mice exhibited significantly greater increases, suggesting that defects in Smad3 lead to heightened iNOS production and susceptibility to septic hypot
Background: The liver is one of the organs most frequently affected by trauma and hemorrhagic shock; the exact role of p38 mitogen-activated protein kinase (MAPK) activation in response to hepatic hemorrhagic shock/resuscitation (HS/R) remains unclear.
Materials And Methods: C57Bl/6 mice were divided into four groups: sham-operated group, SB-only group, control group, and SB + HS/R group. Hepatocellular injury (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) and tumor necrosis factor (TNF-α) and interleukin (IL-1β) messenger ribonucleic acid (mRNA) expression in the liver were assessed 6 h after resuscitation, p38 MAPK activation in the liver was assessed at 30 min after resuscitation.
Article Synopsis
- The article analyzes the treatment and outcomes of severe extensive burn (SEB) patients in China over a 12-year period, focusing on understanding their quality of life (QOL) post-treatment.
- Data from 103 patients with burns covering at least 70% of their body were reviewed, revealing that flame burns were the leading cause, with a significant portion suffering from inhalation injuries and high in-hospital complication rates.
- The study highlights ongoing challenges in treatment, including the need for better functional rehabilitation and improvements in QOL, particularly concerning work, body image, and heat sensitivity.
The present study aims to define the trend of time related changes with local bacterial alteration of bacterial resistance in severe burns in our burn center during a 12-year period. Retrospective analysis of microbiological results on severely burned wounds between 1998 and 2009 was carried out. A study of 3615 microbial isolates was performed.
View Article and Find Full Text PDFBackground: Splanchnic ischemia is common in critically ill patients, and it can result in injury not only of the intestine but also in distant organs, particularly in the lung. Local inflammatory changes play a pivotal role in the development of acute lung injury after intestinal ischemia, but the underlying molecular mechanisms are not fully understood. We sought to examine the role of Toll-like receptor 4 (TLR4) in the mouse model of intestinal ischemia-reperfusion (I/R)-induced lung injury and inflammation.
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- The study investigated the risk factors for lower digestive tract haemorrhage in patients with severe burns, reviewing data from 103 cases admitted to a burn center in Shanghai from 1997 to 2009.
- Out of the patients studied, 5 experienced lower digestive tract haemorrhage, linked to deep burns and systemic infections, with symptoms lasting longer compared to upper digestive tract bleeding.
- The findings suggest that prompt wound management and infection control are crucial for improving patient outcomes related to lower digestive tract haemorrhage in severe burn cases.
Ischemia-reperfusion (I/R) injury of the kidney is a complex pathophysiological process and a major cause of acute renal failure. It has been shown that I/R injury is related to inflammatory responses and activation of apoptotic pathways. Inhibition of certain elements of inflammatory responses and apoptotic pathway seemed to ameliorate renal I/R injury.
View Article and Find Full Text PDFObjective: To identify treatment-related factors associated with mortality in massively burned adult patients.
Methods: This retrospective cohort study examined survival outcomes at a burn unit of 54 beds and 10 burn ICU beds, totaling 900 admissions per year. The cases of 102 adult patients, admitted consecutively from January 1993 to October 2007, with massive burns (burn area>70% of the total body surface area, TBSA) were studied.
Angiotensin II is critically involved in skin wound healing, but the underlying mechanism remains unclear. This study investigated the effect of angiotensin II on type I collagen gene activation in human dermal fibroblasts and the possible mechanism involved. Angiotensin II stimulated the mRNA and protein expression of type I collagen and TGF-beta1.
View Article and Find Full Text PDFObjective: To reveal the characteristic and distribution of length of hospital stay (LOS) and direct hospitalisation costs of paediatric scald.
Methods: A prospective case series observation was performed from January 2005 to December 2006 at the Burn Center, Changhai Hospital, Shanghai, China. The information, such as demographics, clinical diagnosis and treatments since admission, of the paediatric scald patients included in the series was recorded.
The generation of animals lacking Smad proteins has made it possible to explore the contribution of the TGF-beta-Smad signaling to immune activity in vivo. And there have been related issues actively pursued by many laboratories. Here we report that, in contrast to the markedly enhanced inflammatory response, Smad3 gene knockout (Smad3(ex8/ex8)) mice paradoxically show suppressed hepatic acute phase response to the injury induced by lipopolysaccharide (LPS) compared with wild-type mice, characterized by significantly weaker reaction of several typical acute phase proteins in mRNA level.
View Article and Find Full Text PDFObjective: This review was an effort to systematically examine the nationwide data available on pediatric burns requiring hospitalization to reveal burn epidemiology and guide future education and prevention.
Methods: The China Biomedical Disk Database, Chongqing VIP Database, and China Journal Full-Text Database were searched for articles reporting data on children and their burns from January 2000 through December 2005. Studies were included that systematically investigated the epidemiology of pediatric burns requiring hospitalization in China.
Stress ulceration is a common complication in critically ill patients and can result in significant upper gastrointestinal bleeding associated with a high morbidity and mortality. At present, little is known of the molecular mechanisms underlying the incidence of this type of gastric damage. In the present study, we investigated the temporal activation of the redox-sensitive p38 signaling transduction cascade and its roles in a well-defined experimental model of cold immobilization stress-induced gastric ulceration.
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