Publications by authors named "Kai-Xin Ke"
BMP9 has demonstrated significant osteogenic potential. In this study, we investigated the effect of Leptin on BMP9-induced osteogenic differentiation. Firstly, we found Leptin was decreased during BMP9-induced osteogenic differentiation and serum Leptin concentrations were increased in the ovariectomized (OVX) rats.
View Article and Find Full Text PDFBackground: Due to its effective osteogenic ability, BMP9 is a promising candidate for bone regeneration medicine. Whereas, BMP9 can also induce adipogenesis simultaneously. LCN2 is a cytokine associated with osteogenesis and adipogenesis.
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- Interleukin 6 (IL-6) helps control how bones grow but the exact way it works is still a mystery.
- Bone morphogenetic protein 9 (BMP9) is super good at helping bones form, and researchers are studying how IL-6 and BMP9 work together.
- The study shows that increasing IL-6 boosts the bone-building effects of BMP9 in certain cells, and this process involves important pathways in the body called Stat-3 and mTORC1.
Mesenchymal stem cells (MSCs) can self-renew and differentiate into multiple lineages, making MSC transplantation a promising option for bone regeneration. Both matricellular proteins and growth factors play an important role in regulating stem cell fate. In this study, we investigated the effects of matricellular protein SMOC2 (secreted modular calcium-binding protein 2) on bone morphogenetic protein 9 (BMP9) in mouse embryonic fibroblasts (MEFs) and revealed a possible molecular mechanism underlying this process.
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