Publications by authors named "Kai-Uwe Brueggen"
Towards understanding transfluthrin efficacy in a pyrethroid-resistant strain of the malaria vector with special reference to cytochrome P450-mediated detoxification.
Curr Res Parasitol Vector Borne Dis
July 2021
Article Synopsis
- Malaria control heavily depends on insecticides, particularly pyrethroids, but resistance in mosquitoes is increasing due to metabolic adaptations linked to cytochrome P450 enzymes.
- A study evaluated the effectiveness of transfluthrin and multi-halogenated derivatives against pyrethroid-resistant mosquitoes, showing that while these compounds were effective, traditional pyrethroids were quickly detoxified by the resistant strain.
- High-throughput screening for P450 inhibitors led to the discovery of potent fungicides that could enhance the effectiveness of malaria vector control strategies against resistant strains.