[Multisystem inflammatory syndrome in children in the context of coronavirus disease 2019 pandemic].

Multisystem inflammatory syndrome in children (MIS-C) is a complex syndrome characterized by multi-organ involvement that has emerged in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak. The clinical presentation of MIS-C is similar to Kawasaki disease but predominantly presents with fever and gastrointestinal symptoms, and severe cases can involve toxic shock and cardiac dysfunction. Epidemiological findings indicate that the majority of MIS-C patients test positive for SARS-CoV-2 antibodies.

A Cu(OTf)-Catalyzed Glycosylation with Glycosyl --Phthalimidoylpropynyl Benzoates as Donors.

A Cu(OTf)-catalyzed glycosylation protocol using glycosyl --phthalimidoylpropynyl benzoates (NPPBs) as donors was disclosed, which features an inexpensive copper catalyst, operationally convenient conditions, high to excellent yields, and a broad substrate scope. Mechanistic studies indicated an isochromen-4-yl copper(II) intermediate arising from the departure of the leaving group.

[Interpretation of the JCS/JSCS 2020 guideline on diagnosis and management of cardiovascular sequelae in Kawasaki disease].

Kawasaki disease is the main cause of acquired heart disease in children. The cardiovascular sequelae of Kawasaki disease, such as coronary artery lesion and giant coronary aneurysm, have a great impact on children's physical and mental health. The Japanese Circulatory Society and the Japanese Society of Cardiac Surgery jointly released the JCS/JSCS 2020 guideline on diagnosis and management of cardiovascular sequelae in Kawasaki disease in July, 2020, which systematically introduces the advances in the diagnosis and management of cardiovascular sequelae of Kawasaki disease.

[Expression of DeltaNp63 protein in nasopharyngeal carcinoma and its significance].

Background & Objective: The molecular etiology of nasopharyngeal carcinoma is currently unknown. It was reported that DeltaNp63 is dominant-negative toward transactivation of p53, and associated with the malignant hyperplasia and dedifferentiation of the squamous cells. This study was designed to investigate the expression and significance of DeltaNp63 protein in NPC tissues.