Publications by authors named "Kai-Rui Rao"
Article Synopsis
- Six new triterpenoids (euphokanols A-F) and two new C-steroidal glycosides (euphokanosides A and B) were isolated from the roots of Euphorbia kansui, alongside fifty-four known compounds.
- The structures of the new compounds were established using advanced techniques such as NMR spectroscopy and mass spectrometry, with euphokanol A's configuration determined by electronic circular dichroism analysis.
- Several isolated compounds exhibited notable biological activities; for instance, some showed significant inhibition of nitric oxide production, while others demonstrated cytotoxic effects against specific cancer cell lines, particularly euphol, which selectively targeted human glioma stem cells.
A new acylated iridoid, valejatadoid H (), along with fourteen known compounds, were obtained from the -BuOH extract of the roots and rhizomes of , and their structures were elucidated by various spectroscopic methods. Among them, compounds , and exhibited potent inhibition on NO production, with IC values of 4.21, 6.
View Article and Find Full Text PDFFour undescribed ent-kaurane diterpenoids, wilkaunoids A - D (1-4), and three undescribed abietane diterpenoids, wilabinoids A - C (13-15), along with thirteen known ones (5-12 and 16-20), were isolated from Tripterygium wilfordii. Their structures were elucidated by extensive spectroscopic methods, electroniccirculardichroism calculation, and X-ray diffraction analysis. Compounds 1 and 2 were a pair of C-19 epimers of ent-kaurane diterpenoids, featuring a rare 19,20-epoxy-19,20-dimethoxy-kaurane fragment.
View Article and Find Full Text PDFArticle Synopsis
- - A total of 43 quinolizidine alkaloids were extracted from Sophora alopecuroides seeds, including 12 new matrine-type compounds named sophalodes A-L.
- - Four compounds were identified as the first C-11 oxidized matrine-type alkaloids from Sophora species, with their structures confirmed through advanced techniques like spectroscopic methods and X-ray diffraction.
- - Some compounds, particularly 29, 38, and 42, showed strong inhibition of nitric oxide production in macrophages, with compound 29 demonstrating additional anti-inflammatory properties, while compound 16 had mild cytotoxic effects on HeLa cells.
Article Synopsis
- - Three new alkaloids were discovered from the seeds of Sophora alopecuroides L., namely 8β-hydroxyoxysophoridine, 9β-hydroxysophoridine, and 9β-hydroxyisosophocarpine, along with a known compound, 11,12-dehydromatrine.
- - The structures of these new compounds were determined using advanced spectroscopic techniques, including experimental and calculated ECD (Electronic Circular Dichroism) data.
- - Testing for anti-inflammatory properties revealed that 8β-hydroxyoxysophoridine exhibited a notable inhibitory effect on NO production in stimulated RAW 264.7 cells, with an IC value