Publications by authors named "Kai-On Ng"
Synthetic peptide studies on the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein: perspective for SARS vaccine development.
Wai-Yan Choy Shu-Guang Lin Paul Kay-Sheung Chan John Siu-Lun Tam Y M Dennis Lo Ida Miu-Ting Chu Ming-Qi Zhong Kwok-Pui Fung Stephen Kwok-Wing Tsui Kai-On Ng Min Yang Yi-Long Wu Sai-Ming Ngai
Clin Chem
June 2004
Background: The S (spike) protein of the etiologic coronavirus (CoV) agent of severe acute respiratory syndrome (SARS) plays a central role in mediating viral infection via receptor binding and membrane fusion between the virion and the host cell. We focused on using synthetic peptides for developing antibodies against SARS-CoV, which aimed to block viral invasion by eliciting an immune response specific to the native SARS-CoV S protein.
Methods: Six peptide sequences corresponding to the surface regions of SARS-CoV S protein were designed and investigated by use of combined bioinformatics and structural analysis.