Publications by authors named "Kai-Lung Chen"
Background: Epidermal growth factor receptor (EGFR) inhibitors are selective and effective treatments for cancers with relevant mutations. Purpuric drug eruptions are an uncommon but clinically significant dermatological side effect related to EGFR inhibitor use that are associated with positive bacterial cultures and responsive to antibiotic treatment. However, the longitudinal temporal shifts in the skin microbiome that occur before and after antibiotic treatment of purpuric drug eruptions remain largely unknown.
View Article and Find Full Text PDFPemphigus is an autoantibody-mediated blistering disease. In addition to conventional pemphigus vulgaris and pemphigus foliaceus, several other types have been reported. Among them, IgG/IgA pemphigus is less well defined and seldom reported.
View Article and Find Full Text PDFBackground: Multiple comorbidities, including rheumatoid arthritis (RA), have been reported to be associated with psoriasis.
Objective: This study aimed to determine the prevalence and the clinical features of RA among patients with psoriasis in a tertiary referral center.
Methods: Between January 2000 and December 2013, all patients coded with psoriatic disease (ICD-9 CM 696.
Safety data for secukinumab in patients with psoriasis and viral hepatitis are lacking. The aim of this study is to investigate the risk of reactivation of hepatitis B virus (HBV)/hepatitis C virus (HCV) in patients with psoriasis who are receiving secukinumab therapy. This multicentre study screened 284 patients with psoriasis with available HBV and HCV serological data and 63 patients with concurrent HBV/HCV infection were enrolled.
View Article and Find Full Text PDFImportance: Purpuric skin lesions have only rarely been reported in patients receiving epidermal growth factor receptor inhibitors. However, their clinical and histopathologic presentations have varied considerably.
Objective: To characterize purpuric skin eruptions caused by epidermal growth factor receptor inhibitors.
Article Synopsis
- - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin reactions from drugs, leading to skin and mucosal issues, and have limited long-term studies on their complications.
- - A study analyzed 102 patients from 1998 to 2012 and found that the most common long-term complications were skin and eye problems, affecting 44.1% of patients.
- - Additionally, some patients faced severe organ issues, including chronic kidney disease and lung disease, while six patients developed autoimmune disorders such as Sjögren's syndrome and systemic lupus erythematosus.
Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a syndrome involving multiple systems. Liver injury is the most common visceral manifestation.
Objective: The purpose of this study was to investigate the types of liver injury and factors associated with DRESS.