Publications by authors named "Kai-Lun Zhou"
Ring finger protein 187 (RNF187) has been identified to be a co-activator linking c Jun to Ras signaling. However, the expression and function of RNF187 in hepatocellular carcinomas (HCC) remains unclear. Here, we tried to determine the expression and roles of RNF187 in hepatocellular carcinomas (HCC).
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- The study investigates the impact of specific single nucleotide polymorphisms (SNPs) in the HTPAP promoter on its expression and the prognosis of hepatocellular carcinoma (HCC).
- Six SNPs were identified, leading to three distinct promoter haplotypes, with promoter I showing significantly higher activity and expression of HTPAP compared to promoters II and III.
- The presence of promoters II+III is linked to increased metastasis and poorer five-year overall survival in HCC patients, marking it as an adverse prognostic indicator.
[Hepatitis B virus X protein induces malignant transformation tendency of Chang liver cells involving p16(INK4a) hypermethylation].
Beijing Da Xue Xue Bao Yi Xue Ban
December 2012
Objective: To study the relationship between hepatitis B virus X (HBx) protein and DNA methylation of p16(INK4a) and the role of HBx in the carcinogenesis of hepatocellular carcinoma.
Methods: Eukaryonic expression vectors pcDNA3.1B-HBx and pcDNA3.