Enhancing liver fibrosis diagnosis and treatment assessment: a novel biomechanical markers-based machine learning approach.

Accurate diagnosis and treatment assessment of liver fibrosis face significant challenges, including inherent limitations in current techniques like sampling errors and inter-observer variability. Addressing this, our study introduces a novel machine learning (ML) framework, which integrates light gradient boosting machine and multivariate imputation by chained equations to enhance liver status assessment using biomechanical markers. Building upon our previously established multiscale mechanical characteristics in fibrotic and treated livers, this framework employs Gaussian Bayesian optimization for post-imputation, significantly improving classification performance.

Comparing the Performance of Rolled Steel and 3D-Printed 316L Stainless Steel.

Three-dimensional printing is a non-conventional additive manufacturing process. It is different from the conventional subtractive manufacturing process. It offers exceptional rapid prototyping capabilities and results that conventional subtractive manufacturing methods cannot attain, especially in applications involving curved or intricately shaped components.

Fluid-Structure Interaction Based Algorithms for IOP and Corneal Material Behavior.

This paper presents and clinically validates two algorithms for estimating intraocular pressure (IOP) and corneal material behavior using numerical models that consider the fluid-structure interaction between the cornea and the air-puff used in non-contact tonometry. A novel multi-physics fluid-structure interaction model of the air-puff test was employed in a parametric numerical study simulating human eyes under air-puff pressure with a wide range of central corneal thickness (CCT = 445-645 μm), curvature ( = 7.4-8.

Simulation of Air Puff Tonometry Test Using Arbitrary Lagrangian-Eulerian (ALE) Deforming Mesh for Corneal Material Characterisation.

Unlabelled: Purpose: To improve numerical simulation of the non-contact tonometry test by using arbitrary Lagrangian-Eulerian deforming mesh in the coupling between computational fluid dynamics model of an air jet and finite element model of the human eye.

Methods: Computational fluid dynamics model simulated impingement of the air puff and employed Spallart-Allmaras model to capture turbulence of the air jet. The time span of the jet was 30 ms and maximum Reynolds number was Re=2.

Development and validation of a new intraocular pressure estimate for patients with soft corneas.

Purpose: To introduce and clinically validate a new method of estimating intraocular pressure (IOP) in patients with keratoconus and soft corneas with the aim of significantly reducing dependence on corneal biomechanics.

Setting: Vincieye Clinic, Milan, Italy, and Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Brazil.

Design: Retrospective case series.

Determination of Corneal Biomechanical Behavior for Healthy Eyes Using CorVis ST Tonometry: Stress-Strain Index.

This study aims to introduce and clinically validate a new algorithm that can determine the biomechanical properties of the human cornea . A parametric study was conducted involving representative finite element models of human ocular globes with wide ranges of geometries and material biomechanical behavior. The models were subjected to different levels of intraocular pressure (IOP) and the action of external air puff produced by a non-contact tonometer.

Integrating Refined Kano Model and QFD for Service Quality Improvement in Healthy Fast-Food Chain Restaurants.

People are paying greater attention to health. To maintain a good health status and obtain food fast, customers may go to healthy fast-food chain restaurants such as Subway more often than before in China and Taiwan. Healthy fast-food chain restaurants come with a healthy spin, seeking to differentiate themselves from other fast-food restaurants.

Ex-vivo experimental validation of biomechanically-corrected intraocular pressure measurements on human eyes using the CorVis ST.

The purpose of this study was to assess the validity of the Corvis ST (Oculus; Wetzlar, Germany) biomechanical correction algorithm (bIOP) in determining intraocular pressure (IOP) using experiments on ex-vivo human eyes. Five ex-vivo human ocular globes (age 69 ± 3 years) were obtained and tested within 3-5 days post mortem. Using a custom-built inflation rig, the internal pressure of the eyes was controlled mechanically and measured using the CorVis ST (CVS-IOP).

Clinical evaluation of a new correction algorithm for dynamic Scheimpflug analyzer tonometry before and after laser in situ keratomileusis and small-incision lenticule extraction.

Purpose: To compare a biomechanically corrected intraocular pressure (bIOP) algorithm provided by the dynamic Scheimpflug analyzer (Corvis ST) with Goldmann applanation tonometry IOP (Goldmann IOP) and standard dynamic Scheimpflug analyzer IOP measurements before and after laser in situ keratomileusis (LASIK) and refractive lenticule extraction small-incision lenticule extraction (SMILE) surgeries.

Setting: Smile Eye Clinic, Munich, Germany, and University of Liverpool, Liverpool, United Kingdom.

Design: Retrospective case series.

The Relationship Between Mechanical Properties, Ultrastructural Changes, and Intrafibrillar Bond Formation in Corneal UVA/Riboflavin Cross-linking Treatment for Keratoconus.

Purpose: To determine the relationship between mechanical behavior in cross-linked corneas and changes in the corneal ultrastructure after corneal cross-linking (CXL).

Methods: Porcine corneas were treated following the "Dresden" protocol, the current gold standard for clinical treatment, consisting of dropwise application of 0.1% riboflavin in 20% dextran followed by 30 minutes of ultraviolet-A (UVA) irradiation.