Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic .

Analysis of various public databases revealed that gene mutation frequency and mRNA expression are higher in bladder urothelial carcinoma. Further analysis revealed the roles of oncogenic HRAS, autophagy, and cell senescence signaling in bladder cancer cells sensitized to the anticancer drug cisplatin using the phytochemical pterostilbene. A T24 cell line with the oncogenic was chosen for further experiments.

Using the Pleiotropic Characteristics of Curcumin to Validate the Potential Application of a Novel Gene Expression Screening Platform.

Curcumin is a polyphenol derived from that exhibits anticancer and anti-inflammatory properties. The consumption of foods at supernutritional levels to obtain health benefits may paradoxically result in negative health outcomes. In the present study, multiple targeting characteristics of curcumin were analyzed using our gene expression screening system, which utilized the gene expression signatures of curcumin from human hepatocellular carcinoma and colorectal cancer cells to query gene expression databases and effectively identify the molecular actions of curcumin.

Multiwavelength generation from multi-nonlinear optical process in a 2D PPLT.

We have demonstrated multi-wavelength generation in a nonlinear photonic crystals of lithium tantalate. The optical parametric generation leads to second harmonic generation, sum-frequency generation and other frequency conversion in a cascade process. These conversions are assisted by all the optical nonlinear process involving χ and achieved by satisfying the quasi-phase matching conditions.