Publications by authors named "Kai-Hsiang Chan"
Cancer Lett
November 2020
Article Synopsis
- Researchers studied how microRNA affects cancer, specifically looking at glioblastoma multiforme (GBM) and found that microRNA-7 (miR-7) is often downregulated in tumor samples.
- The T-box 2 gene (TBX2) was identified as a target of miR-7, showing that higher TBX2 levels correlate with worse outcomes for patients with GBM.
- Overexpressing miR-7 in GBM cells reduced TBX2 levels, leading to decreased cell invasion and suggesting that the imbalance between miR-7 and TBX2 contributes to increased tumor aggressiveness through epithelial-mesenchymal transition (EMT).
