Publications by authors named "Kai-Hang Lu"
Article Synopsis
- Epidemiological studies have shown that negative prenatal environments can lead to lasting effects on offspring health into adulthood, prompting research on prenatal nicotine exposure (PNE) and its link to increased osteoarthritis (OA) risk in male rats.
- The experiment involved dividing pregnant rats into PNE and control groups, then assessing offspring at 18 months who were exposed to a high-fat diet and exercise, revealing significant joint damage and accelerated OA progression in the PNE group.
- The study found that PNE disrupted key signaling pathways and increased inflammation and apoptosis in joint cartilage, indicating that prenatal conditions can influence the onset and severity of OA, underscoring the importance of early preventative strategies.
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