Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial.

HA121-28, a promising multikinase inhibitor, mainly targets rearranged during transfection (RET) fusions and selectively targets vascular endothelial growth factor receptor-2, endothelial growth factor receptor, and fibroblast growth factor receptor 1-3. The safety, pharmacokinetics, and efficacy of HA121-28 were assessed in advanced solid tumors (phase 1, ClinicalTrials.gov NCT03994484) and advanced RET fusion-positive non-small-cell lung cancer (RET-TKI naive NSCLC, phase 2, ClinicalTrials.

Near-infrared photothermal silk fibroin/polydopamine nanospheres with incorporated silver nanoparticles for efficient antibacterial application.

Bacterial infections and the emergence of drug-resistant after the misuse of antibiotics are threats to human health worldwide. Photothermal nanomaterials incorporating metallic antibacterial agents offer a promising solution. Herein, an antibacterial nanocomposite (Ag@SF@PDA) comprising silver nanoparticles (AgNPs) with silk fibroin/polydopamine nanospheres (SF@PDA) was designed for efficient antibacterial application.

Three-dimensional single-pixel imaging using a fractal superconducting nanowire single-photon detector.

Faint-light imaging plays an important role in applications including fluorescence-lifetime microscopy and remote sensing. Superconducting nanowire single-photon detectors (SNSPDs) outperform other single-photon detectors in terms of comprehensive performance, however, large-format SNSPD imagers with many pixels remain an outstanding technological challenge. Here, as an alternative route, we use a multimode-fiber-coupled fractal SNSPD as the light-sensing element to perform three-dimensional single-pixel imaging at the wavelength of 1560 nm.

Inhibition of Mitochondrial Fission Protein Drp1 Ameliorates Myopathy in the D2-mdx Model of Duchenne Muscular Dystrophy.

Although current treatments for Duchenne Muscular Dystrophy (DMD) have proven to be effective in delaying myopathy, there remains a strong need to identify novel targets to develop additional therapies. Mitochondrial dysfunction is an early pathological feature of DMD. A fine balance of mitochondrial dynamics (fission and fusion) is crucial to maintain mitochondrial function and skeletal muscle health.

Lewis Acid Promotes Three-Component Cyclization to Construct Dithioxazole Derivatives.

A simple and effective strategy for the construction of disulfide-substituted oxazole derivatives from amides, ynals, and acetyl disulfides via a Lewis acid-promoted three-component reaction has been reported. In addition, this reaction possesses other unique advantages, such as transition-metal-free catalysis, the production of disulfides, good functional group tolerance, and good regioselectivity.

Voluntary Exercise Attenuates Tumor Growth in a Preclinical Model of Castration-Resistant Prostate Cancer.

Purpose: To examine the effects of voluntary exercise training on tumor growth and explore the underlying intratumoral molecular pathways and processes responsible for the beneficial effects of VWR on tumor initiation and progression in a mouse model of Castration-Resistant Prostate Cancer (CRPC).

Methods: Male immunodeficient mice (SCID) were castrated and subcutaneously inoculated with human CWR-22RV1 cancer cells to construct CRPC xenograft model before randomly assigned to either voluntary wheel running (VWR) or sedentary (SED) group (n=6/group). After three weeks, tumor tissues were collected.

Energy Absorption Behavior of Carbon-Fiber-Reinforced Plastic Honeycombs under Low-Velocity Impact Considering Their Ply Characteristics.

Honeycomb structures made of carbon-fiber-reinforced plastic (CFRP) are increasingly used in the aerospace field due to their excellent energy absorption capability. Attention has been paid to CFRP structures in order to accurately simulate their progressive failure behavior and discuss their ply designability. In this study, the preparation process of a CFRP corrugated sheet (half of the honeycomb structure) and a CFRP honeycomb structure was illustrated.

Association of visceral adiposity index with sarcopenia based on NHANES data.

The Visceral Adiposity Index (VAI) assesses visceral fat and related metabolic risks. However, its precise correlation with sarcopenia is unclear. This study aimed to examine this correlation.

Long-distance and high-precision ranging with dual-comb nonlinear asynchronous optical sampling.

Precise distance metrology and measurements play an important role in many fields of scientific research and industrial manufacture. Dual-comb laser ranging combines sub-wavelength ranging precision, large non-ambiguity range, and high update rate, making it the most promising candidate in precise distance metrology and measurements. However, previous demonstrations of dual-comb ranging suffer from short working distances, limited by the decoherence of lasers in interferometric schemes or by the low sensitivity of the photodetectors in response to the sparse echo photons.

Do modic changes affect the fusion rate in spinal interbody fusion surgery? A systematic review and network meta-analysis.

Objective: To compare the fusion rates of spinal interbody fusion in patients with modic changes (MCs).

Methods: This meta-analysis was registered at PROSPERO, and the project number was CRD42024538023. This network meta-analysis was conducted according to the PRISMA 2020 statement.

Development and characterization of a first-in-class adjustable-dose gene therapy system.

Introduction: Despite significant potential, gene therapy has been relegated to the treatment of rare diseases, due in part to an inability to adjust dosage following initial administration. Other significant constraints include cost, specificity, antigenicity, and systemic toxicity of current generation technologies. To overcome these challenges, we developed a first-in-class adjustable-dose gene therapy system, with optimized biocompatibility, localization, durability, and cost.

The Relationship Between Modic Changes and Endplate Sclerosis in Patients with Lumbar Degenerative Disease: A Systematic Review and Network Meta-Analysis.

Objective: To explore the relationship between modic changes (MCs) and endplate sclerosis in patients with lumbar degenerative disease.

Methods: This network meta-analysis was performed on the basis of Preffered Reporting Items for Systematic Reviews and Meta-Analysis 2020 statement. This study was registered at the International Prospective Register of Systematic Reviews (CRD42024497370).

The fermentation optimization for alkaline protease production by BS-QR-052.

Introduction: Proteases exhibit a wide range of applications, and among them, alkaline proteases have become a prominent area of research due to their stability in highly alkaline environments. To optimize the production yield and activity of alkaline proteases, researchers are continuously exploring different fermentation conditions and culture medium components.

Methods: In this paper, the fermentation conditions of the alkaline protease (EC 3.

High-timing-precision detection of single X-ray photons by superconducting nanowires.

Precisely acquiring the timing information of individual X-ray photons is important in both fundamental research and practical applications. The timing precision of commonly used X-ray single-photon detectors remains in the range of one hundred picoseconds to microseconds. In this work, we report on high-timing-precision detection of single X-ray photons through the fast transition to the normal state from the superconductive state of superconducting nanowires.

Non-line-of-sight imaging at infrared wavelengths using a superconducting nanowire single-photon detector.

Non-line-of-sight (NLOS) imaging can visualize a remote object out of the direct line of sight and can potentially be used in endoscopy, unmanned vehicles, and robotic vision. In an NLOS imaging system, multiple diffusive reflections of light usually induce large optical attenuation, and therefore, a sensitive and efficient photodetector, or, their array, is required. Limited by the spectral sensitivity of the light sensors, up to now, most of the NLOS imaging experiments are performed in the visible bands, and a few at the near-infrared, 1550 nm.

Enhancement of silicon sub-bandgap photodetection by helium-ion implantation.

Silicon sub-bandgap photodetectors can detect light at the infrared telecommunication wavelengths but with relatively weak photo-response. In this work, we demonstrate the enhancement of sub-bandgap photodetection in silicon by helium-ion implantation, without affecting the transparency that is an important beneficial feature of this type of photodetectors. With an implantation dose of 1 × 10 ions/cm, the minimal detectable optical power can be improved from - 33.

Dual-Signal Feature Spaces Map Protein Subcellular Locations Based on Immunohistochemistry Image and Protein Sequence.

Protein is one of the primary biochemical macromolecular regulators in the compartmental cellular structure, and the subcellular locations of proteins can therefore provide information on the function of subcellular structures and physiological environments. Recently, data-driven systems have been developed to predict the subcellular location of proteins based on protein sequence, immunohistochemistry (IHC) images, or immunofluorescence (IF) images. However, the research on the fusion of multiple protein signals has received little attention.

High-intensity interval training attenuates impairment in regulatory protein machinery of mitochondrial quality control in skeletal muscle of diet-induced obese mice.

Mitochondrial quality control processes are essential in governing mitochondrial integrity and function. The purpose of the study was to examine the effects of 10 weeks of high-intensity interval training (HIIT) on the regulatory protein machinery of skeletal muscle mitochondrial quality control and whole-body glucose homeostasis in diet-induced obese mice. Male C57BL/6 mice were assigned to low-fat diet (LFD) or high-fat diet (HFD) group.

Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice.

Objective: Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial fission. We and others have reported a strong correlation between enhanced Drp1 activity and impaired skeletal muscle insulin sensitivity. This study aimed to determine whether Drp1 directly regulates skeletal muscle insulin sensitivity and whole-body glucose homeostasis.

HAR_Locator: a novel protein subcellular location prediction model of immunohistochemistry images based on hybrid attention modules and residual units.

Proteins located in subcellular compartments have played an indispensable role in the physiological function of eukaryotic organisms. The pattern of protein subcellular localization is conducive to understanding the mechanism and function of proteins, contributing to investigating pathological changes of cells, and providing technical support for targeted drug research on human diseases. Automated systems based on featurization or representation learning and classifier design have attracted interest in predicting the subcellular location of proteins due to a considerable rise in proteins.

Flavonoid Synthesis by sp. 43 Isolated from the Rhizosphere.

Flavonoids are crucial in physiological and pharmaceutical processes, especially the treatment of cancer and the prevention of cardiovascular and cerebrovascular diseases. Flavonoid-producing plants and fungi have been extensively reported, but bacteria have been much less investigated as a source of flavonoid production. sp.

Base-Catalyzed One-Pot Synthesis of 2,3,6-Substituted Pyridines.

A three-component reaction catalyzed by base was established, which mainly consisted of ynals, isocyanates, amines and alcohols. This strategy provides a wide range of substrates and represents a simple process for the preparation of different pyridine derivatives in good yields with high regioselectivities.

Capital endowments and adoption of agricultural green production technologies in China: A meta-regression analysis review.

The promotion of agricultural green production technologies (AGPTs) is a fundamental channel of agricultural sustainable development, and the capital endowments that drive farmers to adopt AGPTs have sparked an enormous interest. Given the mixed findings of 237 primary empirical studies on the link between capital endowments - AGPTs adoption, this systematic quantitative review conducts a meta-regression analysis method to estimate the genuine effects of different capital endowments in terms of eleven proxy factors on AGPTs adoption in China. Combining the estimation strategies of Weighted Least Squares (WLS) and Bayesian Model Averaging (BMA), our findings reveal that three proxy factors (Technical training, Family income, and Government subsidies) are infected by publication bias, and the study-to-study variation between those published studies that focus on these proxy factors stems from several heterogeneity features, such as the types of AGPTs, measurements of adoption decision, and model specification.