Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy.

Background/objectives: Septic cardiomyopathy (SCM) is a severe cardiac complication of sepsis, characterized by cardiac dysfunction with limited effective treatments. This study aimed to identify repurposable drugs for SCM by integrated multi-omics and network analyses.

Methods: We generated a mouse model of SCM induced by lipopolysaccharide (LPS) and then obtained comprehensive metabolic and genetic data from SCM mouse hearts using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and RNA sequencing (RNA-seq).

Analysis of GNSS-RTK Monitoring Background Noise Characteristics Based on Stability Tests.

GNSS-RTK offers numerous advantages and broad prospects in structural dynamic monitoring in civil engineering. However, in practical applications, GNSS-RTK accuracy is susceptible to the monitoring environments, causing actual monitoring accuracy to fall below its calibrated accuracy. This study investigates the monitoring accuracy and spectral characteristics of GNSS-RTK based on stability tests under different environments related to reflection and obstruction conditions (i.

Regulation of LPS-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells via TLR4-Mediated NF-κB and MAPK Signaling Pathways by Lactoferrin.

Lactoferrin (LF), a member of the transferrin family, is widely present in mammalian milk and other secretions, exhibiting anti-inflammatory, antibacterial, and anti-infective properties. Although the biological functions of LF have been extensively studied, there are few reports on its effects and molecular mechanisms concerning bovine mastitis caused by bacterial infection. This study used bovine mammary epithelial cells (BMECs) cultured in vitro as the research model.

Molybdenum Can Regulate the Expression of Molybdase Genes, Affect Molybdase Activity and Metabolites, and Promote the Cell Wall Bio-Synthesis of Tobacco Leaves.

Molybdenum (Mo) is widely used as a micronutrient fertilizer to improve plant growth and soil quality. However, the interactions between cell wall biosynthesis and molybdenum have not been explored sufficiently. This study thoroughly investigated the regulatory effects of different concentrations of Mo on tobacco cell wall biosynthesis from physiological and metabolomic aspects.

Preparation of CHS-FeO@@ZIF-8 peroxidase-mimic with an ultra-thin hollow layer for ultrasensitive electrochemical detection of kanamycin.

A highly sensitive and selective electrochemical biosensor was developed for the detection of kanamycin using a core-hollow-shell structured peroxidase-mimic nanozyme, CHS-Fe₃O₄@@ZIF-8. The synthesized CHS-FeO@@ZIF-8 was characterized with scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. It was found that the CHS-FeO@@ZIF-8 exhibits excellent peroxidase-like activity due to  its ultra-thin hollow layer.

Complete genome sequence of the marine mangrove fungus Sarcopodium sp.QM3-1 confirmed its high potential for antimicrobial activity.

Mangroves, owing to their unique living environment, serve as an important source of natural bioactive compounds. Sarcopodium sp. QM3-1, a marine fungus isolated from mangrove sediments of Quanzhou Bay, exhibited antifungal activity against the plant pathogen Agrobacterium tumefaciens and Magnaporthe oryzae.

LGS-KT: Integrating logical and grammatical skills for effective programming knowledge tracing.

Knowledge tracing (KT) estimates students' mastery of knowledge concepts or skills by analyzing their historical interactions. Although general KT methods have effectively assessed students' knowledge states, specific measurements of students' programming skills remain insufficient. Existing studies mainly rely on exercise outcomes and do not fully utilize behavioral data during the programming process.

Application of modified solidified soil in in-situ backfilling of coal gangue: evaluation of arsenic stabilization effect and mechanism study.

As a typical ecologically fragile area, the Wudong Coal Mine region in Xinjiang generates large accumulations of coal gangue each year, which, in the alkaline soil environment, can easily lead to significant leaching and accumulation of As. This study developed a stabilizer (CFD) using cement, fly ash, and desulfurized gypsum to modify in-situ soil in the Xinjiang mining area, resulting in a modified solidified soil with excellent geotechnical performance and As stabilization capability. The study results showed that when CFD content exceeded 14.

Robot-Assisted Radical Prostatectomy Using the KangDuo Surgical Robot-1500: A Prospective, Multicenter, Single-Arm Clinical Study.

The KangDuo Surgical Robot-1500 (KD-SR-1500) is a newly developed surgical robot. We aim to evaluate the feasibility and efficiency of the KD-SR-1500 system for robot-assisted radical prostatectomy (RARP). This prospective, multicenter, single-arm clinical study was conducted among 18-75-year-old patients with suspected T1-2N0M0 prostate cancer scheduled for RARP.

Teachers' Growth Mindset, Perceived School Climate, and Perceived Parental Autonomy Support Moderate the Relationship Between Students' Growth Mindset and Academic Achievement.

This study investigates the moderating effects of several contextual factors (i.e., teachers' growth mindset, perceived school climate, and perceived parental autonomy support) on the relationship between students' growth mindset and academic achievement.

Extraction camouflage treatment of a skeletal Class III malocclusion with severe anterior crowding by miniscrews and driftodontics in the mandibular dentition.

An 18-year-old Chinese woman presented with chief complaints of crowded teeth and mild mandibular prognathism. Clinical and imaging examinations revealed a concave profile, a protruded chin, increased lower anterior facial height mild, skeletal Class III and Angle's Class III malocclusion, with anterior crossbites, and crowded teeth. Extraction camouflaged therapy combined with miniscrews skeletal anchorage was employed to relieve crowding and retract the mandibular anterior teeth.

Neuronal Dual-Specificity Phosphatase 26 Inhibition via Reactive-Oxygen-Species Responsive Mesoporous-Silica-Loaded Hydrogel for Spinal Cord Injury Repair.

Spinal cord injury (SCI) remains a formidable challenge in biomedical research, as the silencing of intrinsic regenerative signals in most spinal neurons results in an inability to reestablish neural circuits. In this study, we found that neurons with low axonal regeneration after SCI showed decreased extracellular signal-regulated kinase (ERK) phosphorylation levels. However, the expression of dual specificity phosphatase 26 (DUSP26)─which negatively regulates ERK phosphorylation─was reduced considerably in neurons undergoing spontaneous axonal regeneration.

Integration of single-cell transcriptomics and bulk transcriptomics to explore prognostic and immunotherapeutic characteristics of nucleotide metabolism in lung adenocarcinoma.

Background: Lung adenocarcinoma (LUAD) is a highly aggressive tumor with one of the highest morbidity and mortality rates in the world. Nucleotide metabolic processes are critical for cancer development, progression, and alteration of the tumor microenvironment. However, the effect of nucleotide metabolism on LUAD remains to be thoroughly investigated.

Increased production of pullulan in Aureobasidium pullulans YQ65 through reduction of intracellular glycogen content.

Environmental pH is an important parameter that impacts the growth, reproduction, and carbohydrate metabolism of Aureobasidium spp.. This study identifies the ApGph1 gene (encoded with Glycogen Phosphatase) reflecting significant carbohydrate metabolism difference through transcriptome analysis of Aureobasidium Pullulans YQ65 cultured under different pH.

Biomechanical analysis of three kinds of rigid internal fixation methods for condylar head fractures.

Objectives: This study aims to analyze the biomechanics of three kinds of rigid internal fixation methods for condylar head fractures.

Methods: A three dimensional finite element model of the normal mandible was constructed. It was then used to prepare condylar head fracture finite element model and three kinds of rigid internal fixation finite element model (unilateral tension screw, bilateral tension screw, tension screw+titanium plate).

A retrospective study of the effects of different surgical procedures on the mandibular nerve canal involved by odontogenic keratocyst.

Objectives: This study aims to evaluate the changes in the mandibular canal following the treatment of large odontogenic keratocysts through decompression and curettage, providing a theoretical basis for sequential treatment.

Methods: Twenty patients were selected for each decompression and curettage treatment of large odontogenic keratocysts in the mandible. Postoperative follow-up with was conducted every three months, during which cone beam computed tomography (CBCT) scans were performed.

Cognitive frailty in maintenance hemodialysis: a scoping review.

Purpose: To conduct a scoping review of the related research on cognitive frailty (CF) in maintenance hemodialysis (MHD) patients, so as to provide a basis for early diagnosis, treatment and intervention of CF in MHD patients.

Methods: Utilizing a scoping review approach, we searched PubMed, Embase, The Cochrane Library, Web of Science, CINAHL, the China Biological Medicine Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang, and Weipu (VIP) for literature on CF in MHD patients up to October 20, 2024. Two researchers conducted independent screening and data extraction of the literature's fundamental characteristics.

Revitalizing interphase in all-solid-state Li metal batteries by electrophile reduction.

All-solid-state lithium metal batteries promise high levels of safety and energy density, but their practical realization is limited by low Li reversibility, limited cell loading and demand for high-temperature and high-pressure operation, stemming from solid-state electrolyte (SSE) low-voltage reduction and high-voltage decomposition, and from lithium dendrite growth. Here we concurrently address these challenges by reporting that a family of reductive electrophiles gain electrons and cations from metal-nucleophile materials (here a Li sulfide SSE) upon contact to undergo electrochemical reduction and form interphase layers (named solid reductive-electrophile interphase) on material surfaces. The solid reductive-electrophile interphase is electron blocking and lithiophobic, prevents SSE reduction, suppresses Li dendrites and supports high-voltage cathodes.

Expression and Clinical Implications of pro-BNP and Soluble ST2 in Chronic Heart Failure.

Chronic heart failure (CHF) is a complex clinical syndrome resulting from various cardiac diseases, characterized by weakened cardiac pumping capacity and inadequate blood supply to body tissues. This study aims to investigate the expression and clinical implications of pro-B-type natriuretic peptide (pro-BNP) and soluble suppression of tumorigenicity 2 (sST2) in CHF to explore their potential in early diagnosis and severity assessment of the pathological condition. This study included 146 CHF patients treated at our hospital from January 2022 to December 2023, who were classified in the observation group, and 150 concurrent healthy people categorized in the control group.

Global research status and trends of somatic symptom disorder: A bibliometric study.

Background: With the growing scholarly and clinical fascination with somatic symptom disorder (SSD), a bibliometric analysis is lacking.

Aim: To conduct a bibliometric analysis to investigate the current status and frontiers of SSD.

Methods: The documents related to SSD are obtained from the web of science core collection database (WoSCC), and VOSviewer 1.

Dual Active Site Covalent Organic Framework Anode Enables Stable Aqueous Proton Batteries.

Aqueous proton batteries (APBs) have attracted increasing interest owing to their potential for grid-scale energy storage with extraordinary sustainability and excellent rate abilities. However, there are limited anode materials and it remains a great challenge to effectively balance capacity and cycling performance. Here, we report a covalent organic framework containing C=O and C=N dual active sites (TABQ-COF) as a high-capacity and long-cycle anode for proton batteries.

Rad5 and Ubc4 directly ubiquitinate PCNA at Lys164 in vitro.

Ubiquitination of the proliferating cell nuclear antigen (PCNA) by the budding yeast protein Rad5 have important functions in replication stress responses. Rad5 together with the Ubc13-Mms2 complex attaches Lys63-linked ubiquitin chain to a highly conserved Lys164 residue in PCNA. The reaction requires prior PCNA mono-ubiquitination by the Rad6-Rad18 complex and signals for error-free DNA damage tolerance responses.

Co single-atom catalyst on ordered macro-microporous structure as separator for Li-S battery.

Lithium-sulfur (Li-S) batteries have attracted significant attention due to their high theoretical energy density, low cost and environmental friendliness, which are considered one of the most promising candidates for next-generation energy storage devices. However, the sluggish kinetics associated with sulfur oxidation-reduction reactions and the detrimental shuttle effect caused by lithium polysulfides (LiPSs) significantly impacts the electrochemical performance of Li-S batteries. In this work, Co single-atom catalyst (Co-NC) on an ordered macro-microporous structure are designed, and the catalyst are coated onto 2325 separator.

A Hypoxia-Activated BODIPY-Azo Anticancer Prodrug for Bimodal Chemo-Photodynamic Therapy.

For cancer treatment, collaborative strategies have been the mainstream for overcoming the restrictions resulting from monotherapy. Combining chemotherapy with photodynamic therapy (PDT) has been shown to increase the antitumor effect and reduce side impacts. This study reports a hypoxia-activated prodrug BOD-Azo-single with a PDT agent and aniline mustard connected by the azo bond.