Publications by authors named "Kai Yin"

As a common clinical manifestation, muscle weakness is prevalent in people with mobility disorders. Further studies of muscle weakness have found that patients with muscle weakness present with persistent muscle inflammation, loss of muscle fibers, fat infiltration, and interstitial fibrosis. Therefore, we propose the concept of muscle microenvironment homeostasis, which explains the abnormal pathological changes in muscles through the imbalance of muscle microenvironment homeostasis.

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Triple negative breast cancer (TNBC) is characterized by high heterogenicity and aggressiveness and autophagy plays a complicated role in cancer development. Zingerone is reported to possess multiple pharmacological activities, including antitumors. This study explored the biological role and the relevant mechanisms of zingerone in TNBC.

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  • Arsenic-contaminated groundwater, particularly As(III), poses a global environmental challenge due to its toxicity and difficulty in removal; this study focuses on developing a chloramine-functionalized iron hydroxide cellulose nanofibrous membrane (Fe-CNFM-Cl) to address this issue.* -
  • The Fe-CNFM-Cl membrane not only adsorbs As(III) but also oxidizes it to a more removable form, As(V), allowing significant reduction of arsenic levels from 1418.73 μg L to below drinking water standards in about 300 minutes.* -
  • This innovative membrane shows a high capacity for arsenic removal across a wide pH range, can recover its functionality after use
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Modern lifestyle changes, especially the consumption of a diet high in salt, sugar, and fat, have contributed to the increasing incidence and prevalence of chronic metabolic diseases such as diabetes, obesity, and gout. Changing lifestyles continuously shape the gut microbiota which is closely related to the occurrence and development of metabolic diseases due to its specificity of composition and structural diversity. A large number of pathogenic bacteria such as , , , and pathogenic in the gut utilize the type III secretion system (T3SS) to help them resist host defenses and cause disease.

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  • * Both innate immune responses (like neutrophils and macrophages) and adaptive responses (involving T cells and antibodies) significantly influence the progression and activity of atherosclerosis.
  • * Advances in research are uncovering the complex interactions between immune cells and plaque development, suggesting that understanding these relationships may help in developing strategies to treat atherosclerosis.
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  • Endothelial cell (EC) senescence and vascular aging are key factors in chronic metabolic diseases, and understanding how EC senescence is regulated can lead to new treatments.
  • The study found that Spinster homolog 2 (SPNS2) levels are significantly lower in older individuals and models of EC senescence, and its absence leads to worse vascular aging and associated complications in mouse models.
  • Mechanistically, the loss of SPNS2 disrupts pyruvate metabolism, leading to mitochondrial dysfunction and increased cellular senescence, suggesting that SPNS2 plays a vital role in regulating EC health and aging.
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  • - This phase III trial tested the effectiveness and safety of combining camrelizumab, a type of cancer immunotherapy, with low-dose rivoceranib and a chemotherapy regimen (SOX) in patients with advanced gastric or gastroesophageal junction adenocarcinoma.
  • - Patients were randomly assigned to receive either the combination treatment (SOXRC), a different regimen with higher rivoceranib dose (SOXR), or just the chemotherapy (SOX). Only SOXRC and SOX groups are reported here, with strong results supporting the efficacy of SOXRC.
  • - The findings showed that the SOXRC group had a significantly higher rate of pathologic complete response (18.3% vs. 5
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Asymmetric aza-Heck cyclization and coupling reactions offer efficient access to enantioenriched -heterocycles, yet the current studies focus primarily on sequential C-N and C-C bond formation. Herein, we report an enantioselective reductive aza-Heck cyclization followed by a C-S coupling sequence, ultimately yielding sulfide-containing enantioenriched pyrrolines. The reaction is conducted under mild conditions and tolerates broad functionalities including alkynes, phenols, anilines, amides, nitriles, and bromides.

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  • Transformation to small cell lung cancer (SCLC) is a resistance mechanism seen in lung adenocarcinoma (LUAD) patients treated with tyrosine kinase inhibitors, particularly in those with leptomeningeal metastases (LM).
  • In a study of 237 non-small cell lung cancer (NSCLC) patients who had lumbar punctures, SCLC cells were identified in the cerebrospinal fluid (CSF) of 8 patients, all of whom showed resistance to targeted therapies.
  • The results suggest that SCLC transformation in CSF can be detected using cytological evaluation and ctDNA analysis, providing valuable insights into treatment resistance mechanisms, with this transformation correlating with reduced survival rates.
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NLRP3, a crucial member of the NLRP family, plays a pivotal role in immune regulation and inflammatory modulation. Here, we report a potent and specific NLRP3 inhibitor obtained though docking-based virtual screening and structure-activity relationship studies with an IC of 0.26 μM in THP-1 cells and 0.

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Sugarcane smut fungus Sporisorium scitamineum produces polyamines putrescine (PUT), spermidine (SPD), and spermine (SPM) to regulate sexual mating/filamentous growth critical for pathogenicity. Besides de novo biosynthesis, intracellular levels of polyamines could also be modulated by oxidation. In this study, we identified two annotated polyamine oxidation enzymes (SsPAO and SsCuAO1) in S.

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Background: Atherosclerosis (AS) is the most prevalent cardiovascular disease and remains the major contributor to death and mortality globally. Leonurine (LEO) is a unique alkaloid compound with protective effects on the cardiovascular system. However, the exact mechanisms underlying its cardiovascular-protecting action are still not fully elucidated.

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Objectives: Clinical molecular genetic testing and molecular imaging dramatically increase the quantity of clinical data. Combined with the extensive application of electronic health records, a medical data ecosystem is forming, which calls for big-data-based medicine models. We tried to use big data analytics to search for similar patients in a cancer cohort, showing how to apply artificial intelligence (AI) algorithms to clinical data processing to obtain clinically significant results, with the ultimate goal of improving healthcare management.

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Superhydrophobic surfaces have attracted significant attention for their ability to prevent ice formation and facilitate deicing without requiring external energy. However, these surfaces are often vulnerable to damage from external forces, leading to functional failure due to poor mechanical stability, which limits their widespread use. Drawing inspiration from the hierarchical groove of rose petals and the micropapillae of lotus leaves, a simple laser-based method is proposed to create a superhydrophobic surface with a micro/nano hierarchical crater-like structure (HCLS).

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A reversible liquid gating membrane with the ability to regulate gas/liquid transport is critical for many fields, such as biological applications, multiphase separation, and sewerage treatment. Numerous membranes can respond to external stimuli and dynamically control gas/liquid fluid transport; however, simultaneously achieving regulated gas/liquid transport membranes through simple manufacturing remains a challenge. In this work, we investigated an alcohol-regulation gating membrane femtosecond laser one-step processing, allowing dynamically controllable gas/liquid transfer.

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  • * Single-cell RNA sequencing revealed that LMs contain diverse macrophage populations with stronger immunosuppressive characteristics, particularly a subset linked to osimertinib resistance influenced by Midkine (MDK).
  • * Elevated MDK levels in cerebrospinal fluid and plasma correlate with worse patient outcomes, suggesting MDK and the RNASE1_M macrophage subtype could be potential targets for treating LMs in NSCLC patients.
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Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus (DM). Ferroptosis is an atypical form of iron-dependent, modulated cell death that has been shown to occur in human umbilical vein endothelial cells (HUVECs). Leonurine (LEO) is a single active ingredient extracted from .

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This study aimed to determine the prognostic value and microenvironmental crosstalk of exosome-related signatures in human epidermal growth factor receptor 2 positive breast cancer (HER2 BC). Transcriptome sequencing and clinicopathological data were downloaded from the Cancer Genome Atlas. The 10X single cell sequencing dataset was downloaded from the National Center for Biotechnology Information Gene Expression Omnibus.

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N6-methyladenosine (mA), the most abundant modification in mRNAs, affects the fate of the modified RNAs at the post-transcriptional level and participants in various biological and pathological processes. Increasing evidence shows that mA modification plays a role in the progression of many malignancies, including colorectal cancer (CRC). As the only catalytic subunit in methyltransferase complex, methyltransferase-like 3 (METTL3) is essential to the performance of mA modification.

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Esophageal cancer ranks the seventh in cancer incidence and the sixth in cancer death. Esophageal squamous cell carcinoma (ESCC) accounts for approximately 90% of the total cases of esophageal cancer. Chemotherapy is the most effective drug-based method for treatment of esophageal cancer.

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Severe burns related to fires and explosions of lithium-ion batteries of electric motorcycles have not been reported to date. We retrospectively studied 419 patients admitted to our burn intensive care unit from January 2016 to December 2021. Of these 419 patients, 26 (22 male, 4 female; median age, 42 years) had burns related to lithium-ion battery fires and explosions, and all of their injury characteristics were similar to those of traditional flame burns.

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Micro-nano plastics have been reported as important carriers of polycyclic aromatic hydrocarbons (PAHs) for long-distance migration in the environment. However, the combined toxicity from long-term chronic exposure beyond the vehicle-release mechanism remains elusive. In this study, we investigated the synergistic action of Benzo[a]pyrene (BaP) and Polystyrene nanoparticles (PS) in Caenorhabditis elegans (C.

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Lithium-carbon dioxide (Li-CO) battery represents a high-energy density energy storage with excellent real-time CO enrichment and conversion, but its practical utilization is hampered by the development of an excellent catalytic cathode. Here, the synergistic catalytic strategy of designing CoRu bimetallic active sites achieves the electrocatalytic conversion of CO and the efficient decomposition of the discharge products, which in turn realizes the smooth operation of the Li-CO battery. Moreover, obtained support based on metal-organic frameworks precursors facilitates the convenient diffusion and adsorption of CO, resulting in higher reaction concentration and lower mass transfer resistance.

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The solar anti-icing/deicing (SADI) strategy represents an environmentally friendly approach for removing ice efficiently. However, the extensive use of photothermal materials could negatively impact financial performance. Therefore, enhancing light utilization efficiency, especially by optimizing the design of a structure with a low content of photothermal materials, has rapidly become a focal point of research.

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Nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) constitutes an essential inflammasome sensor protein, pivotal in the orchestration of innate immunity. Given its paramount role, NLRP3 has recently emerged as an enticing therapeutic target for disorders associated with inflammation. In this study, we embarked on the design and synthesis of two series of compounds, endowed with the capacity to induce NLRP3 degradation via autophagy-tethering compounds (ATTECs)-an innovative targeted protein degradation technology.

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